CENTA2

ArfGAP with dual PH domains 2

Identifiers

ADAP2; CENTA2; HSA272195; cent-b

External IDs

OMIM: 608635 MGI: 2663075 HomoloGene: 10179 GeneCards: ADAP2 Gene

Gene Ontology
Molecular function	• GTPase activator activity • protein binding • phosphatidylinositol-4,5-bisphosphate binding • phosphatidylinositol-3,4,5-trisphosphate binding • ARF GTPase activator activity • zinc ion binding • protein binding, bridging • phosphatidylinositol-3,4-bisphosphate binding • inositol 1,3,4,5 tetrakisphosphate binding • metal ion binding
Cellular component	• cytoplasm • mitochondrial envelope • plasma membrane
Biological process	• heart development • regulation of ARF GTPase activity • positive regulation of GTPase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
29.25 – 29.29 Mb

Chr 11:
79.97 – 79.99 Mb

PubMed search

[1]

[2]

Arf-GAP with dual PH domain-containing protein 2 is a protein that in humans is encoded by the ADAP2 gene.^[1]

References

^ "Entrez Gene: CENTA2 centaurin, alpha 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55803.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Jenne DE, Tinschert S, Stegmann E et al. (2000). "A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions". Genomics 66 (1): 93–7. doi:10.1006/geno.2000.6179. PMID 10843809.
Whitley P, Gibbard AM, Koumanov F et al. (2003). "Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle". Eur. J. Cell Biol. 81 (4): 222–30. doi:10.1078/0171-9335-00242. PMID 12018390.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Hanck T, Stricker R, Sedehizade F, Reiser G (2004). "Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins". J. Neurochem. 88 (2): 326–36. doi:10.1046/j.1471-4159.2003.02143.x. PMID 14690521.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Venturin M, Bentivegna A, Moroni R et al. (2005). "Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval". Ann. Hum. Genet. 69 (Pt 5): 508–16. doi:10.1111/j.1529-8817.2005.00203.x. PMID 16138909.
Douglas J, Cilliers D, Coleman K et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510.

CENTA2

References

Further reading