Centaurin, alpha 1

ArfGAP with dual PH domains 1

Rendering based on PDB 3FEH.

Available structures
PDB	3FEH, 3FM8, 3MDB

Identifiers

Symbols

ADAP1; CENTA1; GCS1L; p42IP4

External IDs

OMIM: 608114 MGI: 2442201 HomoloGene: 55997 GeneCards: ADAP1 Gene

Gene Ontology
Molecular function	• protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • ARF GTPase activator activity • zinc ion binding • inositol 1,3,4,5 tetrakisphosphate binding • metal ion binding
Cellular component	• nucleus • cytoplasm • plasma membrane
Biological process	• cell surface receptor linked signaling pathway • regulation of ARF GTPase activity • regulation of GTPase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
139.75 – 139.8 Mb

PubMed search

[1]

[2]

Arf-GAP with dual PH domain-containing protein 1 is a protein that in humans is encoded by the ADAP1 gene.^[1]^[2]

Interactions

Centaurin, alpha 1 has been shown to interact with Protein kinase D1,^[3] Nucleolin,^[4] PRKCI,^[3] P110α,^[3] Casein kinase 1, alpha 1^[5]^[6] and Protein kinase Mζ.^[3]

References

^ Venkateswarlu K, Oatey PB, Tavare JM, Jackson TR, Cullen PJ (Jul 1999). "Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1". Biochem J 340 ( Pt 2): 359–63. PMC 1220257. PMID 10333475. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220257.
^ "Entrez Gene: CENTA1 centaurin, alpha 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11033.
^ ^a ^b ^c ^d Zemlickova, Eva; Dubois Thierry, Kerai Preeti, Clokie Sam, Cronshaw Andy D, Wakefield Robert I D, Johannes Franz-Josef, Aitken Alastair (Aug. 2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochem. Biophys. Res. Commun. (United States) 307 (3): 459–65. doi:10.1016/S0006-291X(03)01187-2. ISSN 0006-291X. PMID 12893243.
^ Dubois, Thierry; Zemlickova Eva, Howell Steven, Aitken Alastair (Feb. 2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochem. Biophys. Res. Commun. (United States) 301 (2): 502–8. doi:10.1016/S0006-291X(02)03010-3. ISSN 0006-291X. PMID 12565890.
^ Dubois, Thierry; Howell Steven, Zemlickova Eva, Aitken Alastair (Apr. 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Lett. (Netherlands) 517 (1-3): 167–71. doi:10.1016/S0014-5793(02)02614-5. ISSN 0014-5793. PMID 12062430.
^ Dubois, T; Kerai P, Zemlickova E, Howell S, Jackson T R, Venkateswarlu K, Cullen P J, Theibert A B, Larose L, Roach P J, Aitken A (Jun. 2001). "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". J. Biol. Chem. (United States) 276 (22): 18757–64. doi:10.1074/jbc.M010005200. ISSN 0021-9258. PMID 11278595.

Venkateswarlu K, Cullen PJ (1999). "Molecular cloning and functional characterization of a human homologue of centaurin-alpha.". Biochem. Biophys. Res. Commun. 262 (1): 237–44. doi:10.1006/bbrc.1999.1065. PMID 10448098.
Dubois T, Kerai P, Zemlickova E, et al. (2001). "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins.". J. Biol. Chem. 276 (22): 18757–64. doi:10.1074/jbc.M010005200. PMID 11278595.
Sedehizade F, Hanck T, Stricker R, et al. (2002). "Cellular expression and subcellular localization of the human Ins(1,3,4,5)P(4)-binding protein, p42(IP4), in human brain and in neuronal cells.". Brain Res. Mol. Brain Res. 99 (1): 1–11. doi:10.1016/S0169-328X(01)00335-7. PMID 11869802.
Whitley P, Gibbard AM, Koumanov F, et al. (2003). "Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle.". Eur. J. Cell Biol. 81 (4): 222–30. doi:10.1078/0171-9335-00242. PMID 12018390.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Reiser G, Bernstein HG (2003). "Neurons and plaques of Alzheimer's disease patients highly express the neuronal membrane docking protein p42IP4/centaurin alpha.". Neuroreport 13 (18): 2417–9. doi:10.1097/01.wnr.0000048005.96487.10. PMID 12499840.
Dubois T, Zemlickova E, Howell S, Aitken A (2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin.". Biochem. Biophys. Res. Commun. 301 (2): 502–8. doi:10.1016/S0006-291X(02)03010-3. PMID 12565890.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Zemlickova E, Dubois T, Kerai P, et al. (2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.". Biochem. Biophys. Res. Commun. 307 (3): 459–65. doi:10.1016/S0006-291X(03)01187-2. PMID 12893243.
Venkateswarlu K, Brandom KG, Lawrence JL (2004). "Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization.". J. Biol. Chem. 279 (8): 6205–8. doi:10.1074/jbc.C300482200. PMID 14625293.
Hanck T, Stricker R, Sedehizade F, Reiser G (2004). "Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins.". J. Neurochem. 88 (2): 326–36. doi:10.1046/j.1471-4159.2003.02143.x. PMID 14690521.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Reiser G, Bernstein HG (2004). "Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin.". Neuroreport 15 (1): 147–8. doi:10.1097/00001756-200401190-00028. PMID 15106847.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Thacker E, Kearns B, Chapman C, et al. (2005). "The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton.". Eur. J. Cell Biol. 83 (10): 541–54. doi:10.1078/0171-9335-00416. PMID 15679100.
Lawrence J, Mundell SJ, Yun H, et al. (2005). "Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization.". Mol. Pharmacol. 67 (6): 1822–8. doi:10.1124/mol.105.011338. PMID 15778454.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hayashi H, Matsuzaki O, Muramatsu S, et al. (2006). "Centaurin-alpha1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases.". J. Biol. Chem. 281 (3): 1332–7. doi:10.1074/jbc.M505905200. PMID 16287813.
Sedehizade F, von Klot C, Hanck T, Reiser G (2006). "p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor.". Neurochem. Res. 30 (10): 1319–30. doi:10.1007/s11064-005-8804-1. PMID 16341594.

Centaurin, alpha 1

Interactions

References

Further reading