CDON
Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene.[1][2]
CDON and BOC (MIM 608708) are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM][2]
Interactions
CDON has been shown to interact with CDH1[3] and BOC.[4]
References
- ^ Kang JS, Gao M, Feinleib JL, Cotter PD, Guadagno SN, Krauss RS (Aug 1997). "CDO: An Oncogene-, Serum-, and Anchorage-regulated Member of the Ig/Fibronectin Type III Repeat Family". J Cell Biol 138 (1): 203–13. doi:10.1083/jcb.138.1.203. PMC 2139939. PMID 9214393. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2139939.
- ^ a b "Entrez Gene: CDON Cdon homolog (mouse)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50937.
- ^ Kang, Jong-Sun; Feinleib Jessica L, Knox Sarah, Ketteringham Michael A, Krauss Robert S (Apr. 2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (7): 3989–94. doi:10.1073/pnas.0736565100. ISSN 0027-8424. PMC 153035. PMID 12634428. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=153035.
- ^ Kang, Jong-Sun; Mulieri Philip J, Hu Yulan, Taliana Lavinia, Krauss Robert S (Jan. 2002). "BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation". EMBO J. (England) 21 (1–2): 114–24. doi:10.1093/emboj/21.1.114. ISSN 0261-4189. PMC 125805. PMID 11782431. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125805.
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Wegorzewska M, Krauss RS, Kang JS (2003). "Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD". Mol. Carcinog. 37 (1): 1–4. doi:10.1002/mc.10121. PMID 12720294.
- Kang JS, Feinleib JL, Knox S, et al. (2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 3989–94. doi:10.1073/pnas.0736565100. PMC 153035. PMID 12634428. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=153035.
- Cole F, Krauss RS (2003). "Microform holoprosencephaly in mice that lack the Ig superfamily member Cdon". Curr. Biol. 13 (5): 411–5. doi:10.1016/S0960-9822(03)00088-5. PMID 12620190.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kang JS, Mulieri PJ, Hu Y, et al. (2002). "BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation". EMBO J. 21 (1–2): 114–24. doi:10.1093/emboj/21.1.114. PMC 125805. PMID 11782431. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125805.