CDCA8
Borealin is a protein that in humans is encoded by the CDCA8 gene.[1][2][3]
CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle (Gassmann et al., 2004).[supplied by OMIM][3]
Interactions
CDCA8 has been shown to interact with INCENP,[4] Survivin[2][4] and Aurora B kinase.[2][4]
References
- ^ Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
- ^ a b c Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell 118 (2): 187–202. doi:10.1016/j.cell.2004.06.026. PMID 15260989.
- ^ a b "Entrez Gene: CDCA8 cell division cycle associated 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55143.
- ^ a b c Gassmann, Reto; Carvalho Ana, Henzing Alexander J, Ruchaud Sandrine, Hudson Damien F, Honda Reiko, Nigg Erich A, Gerloff Dietlind L, Earnshaw William C (Jul. 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. (United States) 166 (2): 179–91. doi:10.1083/jcb.200404001. ISSN 0021-9525. PMC 2172304. PMID 15249581. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172304.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gassmann R, Carvalho A, Henzing AJ et al. (2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172304.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Sauer G, Körner R, Hanisch A et al. (2005). "Proteome analysis of the human mitotic spindle". Mol. Cell Proteomics 4 (1): 35–43. doi:10.1074/mcp.M400158-MCP200. PMID 15561729.
- Andersen JS, Lam YW, Leung AK et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Vader G, Kauw JJ, Medema RH, Lens SM (2006). "Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody". EMBO Rep. 7 (1): 85–92. doi:10.1038/sj.embor.7400562. PMC 1369225. PMID 16239925. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1369225.
- Noton EA, Colnaghi R, Tate S et al. (2006). "Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis". J. Biol. Chem. 281 (2): 1286–95. doi:10.1074/jbc.M508773200. PMID 16291752.
- Chang JL, Chen TH, Wang CF et al. (2006). "Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer". Exp. Cell Res. 312 (7): 962–73. doi:10.1016/j.yexcr.2005.12.015. PMID 16427043.
- Lens SM, Rodriguez JA, Vader G et al. (2006). "Uncoupling the Central Spindle-associated Function of the Chromosomal Passenger Complex from Its Role at Centromeres". Mol. Biol. Cell 17 (4): 1897–909. doi:10.1091/mbc.E05-08-0727. PMC 1415303. PMID 16436504. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1415303.
- Rodriguez JA, Lens SM, Span SW et al. (2006). "Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown". Oncogene 25 (35): 4867–79. doi:10.1038/sj.onc.1209499. PMID 16547492.
- Nousiainen M, Silljé HH, Sauer G et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1459365.
- Klein UR, Nigg EA, Gruneberg U (2006). "Centromere Targeting of the Chromosomal Passenger Complex Requires a Ternary Subcomplex of Borealin, Survivin, and the N-Terminal Domain of INCENP". Mol. Biol. Cell 17 (6): 2547–58. doi:10.1091/mbc.E05-12-1133. PMC 1474794. PMID 16571674. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1474794.
- Kaur H, Stiff AC, Date DA, Taylor WR (2007). "Analysis of mitotic phosphorylation of Borealin". BMC Cell Biol. 8: 5. doi:10.1186/1471-2121-8-5. PMC 1794407. PMID 17241471. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1794407.
- Hayama S, Daigo Y, Yamabuki T et al. (2007). "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis". Cancer Res. 67 (9): 4113–22. doi:10.1158/0008-5472.CAN-06-4705. PMID 17483322.