CDC5L
Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.[1][2][3]
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.[3]
Interactions
CDC5L has been shown to interact with SRRM1,[4] RPS25,[4] SF3B1,[4] ILF2,[4] CWC15,[4] DNA-PKcs,[4] GCN1L1,[4] BZW1,[4] TTF2,[5] SF3B2,[4] SFRS2,[4] ASF/SF2,[4] PLRG1,[4][6][7][8] DYNC1H1,[4] PPP1CA,[4] Small nuclear ribonucleoprotein D1,[4] SF3B4,[4] Small nuclear ribonucleoprotein polypeptide A,[4] SNRPA1,[4] RPS16,[4] Small nuclear ribonucleoprotein D2,[4] SNRPD3,[4] PRPF19,[4] HSPA8,[4] SF3A1,[4] SFPQ,[4] TOP2A,[4] PPM1D,[4] RPL13,[4] RBMX[4] and RPL12.[4]
References
- ^ Groenen PM, Vanderlinden G, Devriendt K, Fryns JP, Van de Ven WJ (Aug 1998). "Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia". Genomics 49 (2): 218–29. doi:10.1006/geno.1998.5254. PMID 9598309.
- ^ Bernstein HS, Coughlin SR (Apr 1997). "Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling". J Biol Chem 272 (9): 5833–7. doi:10.1074/jbc.272.9.5833. PMID 9038199.
- ^ a b "Entrez Gene: CDC5L CDC5 cell division cycle 5-like (S. pombe)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=988.
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad Ajuh, P; Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (Dec. 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305846.
- ^ Leonard, Deana; Ajuh Paul, Lamond Angus I, Legerski Randy J (Sep. 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. (United States) 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. ISSN 0006-291X. PMID 12927788.
- ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
- ^ Ajuh, Paul; Lamond Angus I (Nov. 2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Res. (England) 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC 275459. PMID 14576297. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=275459.
- ^ Ajuh, P; Sleeman J, Chusainow J, Lamond A I (Nov. 2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". J. Biol. Chem. (United States) 276 (45): 42370–81. doi:10.1074/jbc.M105453200. ISSN 0021-9258. PMID 11544257.
Further reading
- Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Heaney JP, Jacobson A (1975). "Simplified control of upper abdominal hemorrhage from the vena cava.". Surgery 78 (2): 138–41. PMID 1154257.
- Hirayama T, Shinozaki K (1996). "A cdc5+ homolog of a higher plant, Arabidopsis thaliana.". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 13371–6. doi:10.1073/pnas.93.23.13371. PMC 24100. PMID 8917598. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24100.
- Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
- Bernstein HS, Coughlin SR (1998). "A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry.". J. Biol. Chem. 273 (8): 4666–71. doi:10.1074/jbc.273.8.4666. PMID 9468527.
- Ohi R, Feoktistova A, McCann S, et al. (1998). "Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes.". Mol. Cell. Biol. 18 (7): 4097–108. PMC 108994. PMID 9632794. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108994.
- Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
- Burns CG, Ohi R, Krainer AR, Gould KL (2000). "Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing.". Proc. Natl. Acad. Sci. U.S.A. 96 (24): 13789–94. doi:10.1073/pnas.96.24.13789. PMC 24143. PMID 10570151. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24143.
- Boudrez A, Beullens M, Groenen P, et al. (2000). "NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry.". J. Biol. Chem. 275 (33): 25411–7. doi:10.1074/jbc.M001676200. PMID 10827081.
- Lei XH, Shen X, Xu XQ, Bernstein HS (2001). "Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein.". J. Cell. Sci.. 113 Pt 24: 4523–31. PMID 11082045.
- Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305846.
- Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
- Ajuh P, Sleeman J, Chusainow J, Lamond AI (2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing.". J. Biol. Chem. 276 (45): 42370–81. doi:10.1074/jbc.M105453200. PMID 11544257.
- Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370266.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing.". Biochem. Biophys. Res. Commun. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
- Liu L, Gräub R, Hlaing M, et al. (2004). "Distinct domains of human CDC5 direct its nuclear import and association with the spliceosome.". Cell Biochem. Biophys. 39 (2): 119–32. doi:10.1385/CBB:39:2:119. PMID 14515018.
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PDB gallery
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2dim: Solution structure of the Myb_DNA-binding domain of human Cell division cycle 5-like protein
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2din: Solution structure of the Myb_DNA-binding domain of human Cell division cycle 5-like protein
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