CDC2L2

Cyclin-dependent kinase 11A

Identifiers

CDK11A; CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; MGC131975; PITSLRE; p58GTA

External IDs

OMIM: 116951 HomoloGene: 22416 GeneCards: CDK11A Gene

2.7.11.22

Gene Ontology
Molecular function	• nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • cyclin-dependent protein kinase activity • protein binding • ATP binding
Cellular component	• nucleus • cytoplasm
Biological process	• regulation of cell growth • regulation of transcription, DNA-dependent • protein phosphorylation • protein phosphorylation • apoptosis • mitosis • regulation of mRNA processing

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
1.57 – 1.66 Mb

Chr 4:
155 – 155.02 Mb

PubMed search

[1]

[2]

PITSLRE serine/threonine-protein kinase CDC2L2 is an enzyme that in humans is encoded by the CDC2L2 gene.^[1]^[2]^[3]

References

^ Lahti JM, Valentine M, Xiang J, Jones B, Amann J, Grenet J, Richmond G, Look AT, Kidd VJ (Nov 1994). "Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma". Nat Genet 7 (3): 370–5. doi:10.1038/ng0794-370. PMID 7920654.
^ Gururajan R, Lahti JM, Grenet J, Easton J, Gruber I, Ambros PF, Kidd VJ (Nov 1998). "Duplication of a Genomic Region Containing the Cdc2L1-2 and MMP21-22 Genes on Human Chromosome 1p36.3 and their Linkage to D1Z2". Genome Res 8 (9): 929–39. doi:10.1101/gr.8.9.929. PMC 310781. PMID 9750192. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310781.
^ "Entrez Gene: LOC728642 similar to cell division cycle 2-like 1 (PITSLRE proteins) isoform 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=728642.

Eipers PG, Lahti JM, Kidd VJ (1992). "Structure and expression of the human p58clk-1 protein kinase chromosomal gene". Genomics 13 (3): 613–21. doi:10.1016/0888-7543(92)90132-C. PMID 1639388.
Eipers PG, Barnoski BL, Han J et al. (1992). "Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15". Genomics 11 (3): 621–9. doi:10.1016/0888-7543(91)90069-Q. PMID 1774066.
Bunnell BA, Heath LS, Adams DE et al. (1990). "Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7467–71. doi:10.1073/pnas.87.19.7467. PMC 54768. PMID 2217177. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=54768.
White PS, Maris JM, Beltinger C et al. (1995). "A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5520–4. doi:10.1073/pnas.92.12.5520. PMC 41727. PMID 7777541. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41727.
Xiang J, Lahti JM, Grenet J et al. (1994). "Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms". J. Biol. Chem. 269 (22): 15786–94. PMID 8195233.
Beyaert R, Kidd VJ, Cornelis S et al. (1997). "Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor". J. Biol. Chem. 272 (18): 11694–7. doi:10.1074/jbc.272.18.11694. PMID 9115219.
Loyer P, Trembley JH, Lahti JM, Kidd VJ (1998). "The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo". J. Cell. Sci. 111 ( Pt 11): 1495–506. PMID 9580558.
Tang D, Gururajan R, Kidd VJ (1998). "Phosphorylation of PITSLRE p110 isoforms accompanies their processing by caspases during Fas-mediated cell death". J. Biol. Chem. 273 (26): 16601–7. doi:10.1074/jbc.273.26.16601. PMID 9632733.
Gururajan R, Grenet J, Lahti JM, Kidd VJ (1999). "Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3". Genomics 52 (1): 101–6. doi:10.1006/geno.1998.5401. PMID 9740677.
Cornelis S, Bruynooghe Y, Denecker G et al. (2000). "Identification and characterization of a novel cell cycle-regulated internal ribosome entry site". Mol. Cell 5 (4): 597–605. doi:10.1016/S1097-2765(00)80239-7. PMID 10882096.
Venter JC, Adams MD, Myers EW et al. (2001). "The sequence of the human genome". Science 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
Zhang SW, Xu SL, Cai MM et al. (2002). "Effect of p58GTA on beta-1,4-galactosyltransferase 1 activity and cell-cycle in human hepatocarcinoma cells". Mol. Cell. Biochem. 221 (1–2): 161–8. doi:10.1023/A:1010932211745. PMID 11506180.
Berke JD, Sgambato V, Zhu PP et al. (2001). "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin". Neuron 32 (2): 277–87. doi:10.1016/S0896-6273(01)00465-2. PMID 11683997.
Dickinson LA, Edgar AJ, Ehley J, Gottesfeld JM (2002). "Cyclin L is an RS domain protein involved in pre-mRNA splicing". J. Biol. Chem. 277 (28): 25465–73. doi:10.1074/jbc.M202266200. PMID 11980906.
Shi J, Feng Y, Goulet AC et al. (2003). "The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis". J. Biol. Chem. 278 (7): 5062–71. doi:10.1074/jbc.M206427200. PMID 12446680.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Hu D, Mayeda A, Trembley JH et al. (2003). "CDK11 complexes promote pre-mRNA splicing". J. Biol. Chem. 278 (10): 8623–9. doi:10.1074/jbc.M210057200. PMID 12501247.
Chen S, Yin X, Zhu X et al. (2003). "The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis". J. Biol. Chem. 278 (22): 20029–36. doi:10.1074/jbc.M300818200. PMID 12624090.

CDC2L2

References

Further reading