CDC14A

CDC14 cell division cycle 14 homolog A (S. cerevisiae)

Identifiers

CDC14A; cdc14; hCDC14

External IDs

OMIM: 603504 MGI: 2442676 HomoloGene: 75343 GeneCards: CDC14A Gene

Gene Ontology
Molecular function	• phosphoprotein phosphatase activity • protein tyrosine phosphatase activity • protein binding • protein tyrosine/serine/threonine phosphatase activity • hydrolase activity
Cellular component	• nucleus • nucleolus • cytoplasm • centrosome • spindle • cytoskeleton
Biological process	• cell cycle • cell proliferation • cell division
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
100.81 – 100.99 Mb

Chr 3:
115.98 – 116.13 Mb

PubMed search

[1]

[2]

Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.^[1]^[2]^[3]

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.^[3]

Interactions

CDC14A has been shown to interact with P53.^[4]

References

^ Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (Dec 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". J Biol Chem 272 (47): 29403–6. doi:10.1074/jbc.272.47.29403. PMID 9367992.
^ Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH (Sep 1999). "Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene". Genomics 59 (2): 248–51. doi:10.1006/geno.1999.5863. PMID 10409437.
^ ^a ^b "Entrez Gene: CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8556.
^ Li, L; Ljungman M, Dixon J E (Jan. 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. (UNITED STATES) 275 (4): 2410–4. doi:10.1074/jbc.275.4.2410. ISSN 0021-9258. PMID 10644693.

Li L, Ljungman M, Dixon JE (2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. 275 (4): 2410–4. doi:10.1074/jbc.275.4.2410. PMID 10644693.
Bembenek J, Yu H (2002). "Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a". J. Biol. Chem. 276 (51): 48237–42. doi:10.1074/jbc.M108126200. PMID 11598127.
Mailand N, Lukas C, Kaiser BK, et al. (2002). "Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation". Nat. Cell Biol. 4 (4): 317–22. doi:10.1038/ncb777. PMID 11901424.
Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK (2003). "Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase". Mol. Biol. Cell 13 (7): 2289–300. doi:10.1091/mbc.01-11-0535. PMC 117313. PMID 12134069. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=117313.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gruneberg U, Neef R, Honda R, et al. (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2". J. Cell Biol. 166 (2): 167–72. doi:10.1083/jcb.200403084. PMC 2172317. PMID 15263015. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172317.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP (2005). "Functional homology among human and fission yeast Cdc14 phosphatases". J. Biol. Chem. 280 (32): 29144–50. doi:10.1074/jbc.M413328200. PMID 15911625.
Zhao H, Wang Q, Zhang H, et al. (2006). "UXT is a novel centrosomal protein essential for cell viability". Mol. Biol. Cell 16 (12): 5857–65. doi:10.1091/mbc.E05-08-0705. PMC 1289427. PMID 16221885. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1289427.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Sanchez M, Galy B, Dandekar T, et al. (2006). "Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy". J. Biol. Chem. 281 (32): 22865–74. doi:10.1074/jbc.M603876200. PMID 16760464.
Paulsen MT, Starks AM, Derheimer FA, et al. (2006). "The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers". Mol. Cancer 5: 25. doi:10.1186/1476-4598-5-25. PMC 1524803. PMID 16784539. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1524803.
Esteban V, Vázquez-Novelle MD, Calvo E, et al. (2007). "Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320". Cell Cycle 5 (24): 2894–8. PMID 17172867.
Lanzetti L, Margaria V, Melander F, et al. (2007). "Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells". J. Biol. Chem. 282 (20): 15258–70. doi:10.1074/jbc.M700914200. PMID 17371873.
Yuan K, Hu H, Guo Z, et al. (2007). "Phospho-regulation of HsCdc14A By Polo-like kinase 1 is essential for mitotic progression". J. Biol. Chem. 282 (37): 27414–23. doi:10.1074/jbc.M703555200. PMID 17623655.

Esterase: protein tyrosine phosphatases (EC 3.1.3.48)

Class I

Classical PTPs	Receptor type PTPs (PTPRA, PTPRB, PTPRC, PTPRD, PTPRE, PTPRF, PTPRG, PTPRH, PTPRJ, PTPRK, PTPRM, PTPRN, PTPRN2, PTPRO, PTPRQ, PTPRR, PTPRS, PTPRT, PTPRU, PTPRZ1, PTPRZ2) Non receptor type PTPs (PTPN1, PTPN2, PTPN3, PTPN4, PTPN5, PTPN6, PTPN7, PTPN9, PTPN11, PTPN12, PTPN13, PTPN14, PTPN18, PTPN20, PTPN21, PTPN22, PTPN23

VH1-like or dual specific phosphatases (DSPs)	MAPK phosphatases (MKPs) (DUSP1, DUSP2, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, DUSP10, DUSP16, MK-STYX) Slingshots (SSH1, SSH2, SSH3) PRLs (PTP4A1, PTP4A2, PTP4A3) CDC14s (CDC14A, CDC14B, CDKN3, PTP9Q22) Atypical DSPs (DUSP3, DUSP11, DUSP12, DUSP13A, DUSP13B, DUSP14, DUSP15, DUSP18, DUSP19, DUSP21, DUSP22, DUSP23, DUSP24, DUSP25, DUSP26, DUSP27, EMP2A, RNGTT, STYX) Phosphatase and tensin homologs (PTENs) (PTEN, TPIP, TPTE, TNS, TENC1) Myotubularins (MTM1, MTMR2, MTMR3, MTMR4, MTMR5, MTMR6, MTMR7, MTMR8, MTMR9, MTMR10, MTMR11, MTMR12, MTMR13, MTMR14, MTMR15)

Class II

ACP1

Class III

Cdc25: CDC25A, CDC25B, CDC25C

Class IV

Eyes absent homolog (EYA1, EYA2, EYA3, EYA4)

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

CDC14A

Interactions

References

Further reading