CD83

CD83 molecule

Identifiers

CD83; BL11; HB15

External IDs

OMIM: 604534 MGI: 1328316 HomoloGene: 3121 GeneCards: CD83 Gene

Gene Ontology
Cellular component	• plasma membrane • integral to plasma membrane • external side of plasma membrane
Biological process	• defense response • humoral immune response • signal transduction • response to organic cyclic compound • negative regulation of interleukin-4 production • positive regulation of interleukin-10 production • positive regulation of interleukin-2 production • positive regulation of CD4-positive, alpha-beta T cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
14.12 – 14.14 Mb

Chr 13:
43.88 – 43.9 Mb

PubMed search

[1]

[2]

CD83 (Cluster of Differentiation 83) is a human protein encoded by the CD83 gene.^[1]

1 See also
2 References
3 Further reading
4 External links

References

^ "Entrez Gene: CD83 CD83 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9308.

Lechmann M, Berchtold S, Hauber J, Steinkasserer A (2002). "CD83 on dendritic cells: more than just a marker for maturation.". Trends Immunol. 23 (6): 273–5. doi:10.1016/S1471-4906(02)02214-7. PMID 12072358.
Zhou LJ, Schwarting R, Smith HM, Tedder TF (1992). "A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily.". J. Immunol. 149 (2): 735–42. PMID 1378080.
Zhou LJ, Tedder TF (1995). "Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.". J. Immunol. 154 (8): 3821–35. PMID 7706722.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kozlow EJ, Wilson GL, Fox CH, Kehrl JH (1993). "Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes". Blood 81 (2): 454–61. PMID 8422464.
de la Fuente MA (1997). "CD84 leukocyte antigen is a new member of the Ig superfamily". Blood 90 (6): 2398–405. PMID 9310491.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Olavesen MG, Bentley E, Mason RV et al. (1998). "Fine mapping of 39 ESTs on human chromosome 6p23-p25". Genomics 46 (2): 303–6. doi:10.1006/geno.1997.5032. PMID 9417921.
Twist CJ, Beier DR, Disteche CM et al. (1998). "The mouse Cd83 gene: structure, domain organization, and chromosome localization". Immunogenetics 48 (6): 383–93. doi:10.1007/s002510050449. PMID 9799334.
Berchtold S, Mühl-Zürbes P, Heufler C et al. (1999). "Cloning, recombinant expression and biochemical characterization of the murine CD83 molecule which is specifically upregulated during dendritic cell maturation". FEBS Lett. 461 (3): 211–6. doi:10.1016/S0014-5793(99)01465-9. PMID 10567699.
Scholler N, Hayden-Ledbetter M, Hellström KE et al. (2001). "CD83 is a sialic acid-binding Ig-like lectin (Siglec) adhesion receptor that binds monocytes and a subset of activated CD8+ T cells". J. Immunol. 166 (6): 3865–72. PMID 11238630.
Fanales-Belasio E, Moretti S, Nappi F et al. (2002). "Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses". J. Immunol. 168 (1): 197–206. PMID 11751963.
Berchtold S, Mühl-Zürbes P, Maczek E et al. (2003). "Cloning and characterization of the promoter region of the human CD83 gene". Immunobiology 205 (3): 231–46. doi:10.1078/0171-2985-00128. PMID 12182451.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
te Velde AA, van Kooyk Y, Braat H et al. (2003). "Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease". Eur. J. Immunol. 33 (1): 143–51. doi:10.1002/immu.200390017. PMID 12594843.
Dudziak D, Kieser A, Dirmeier U et al. (2003). "Latent Membrane Protein 1 of Epstein-Barr Virus Induces CD83 by the NF-κB Signaling Pathway". J. Virol. 77 (15): 8290–8. doi:10.1128/JVI.77.15.8290-8298.2003. PMC 165234. PMID 12857898. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=165234.
Hock BD, Haring LF, Steinkasserer A et al. (2004). "The soluble form of CD83 is present at elevated levels in a number of hematological malignancies". Leuk. Res. 28 (3): 237–41. doi:10.1016/S0145-2126(03)00255-8. PMID 14687618.
Sénéchal B, Boruchov AM, Reagan JL et al. (2004). "Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83". Blood 103 (11): 4207–15. doi:10.1182/blood-2003-12-4350. PMID 14962896.
Cao W, Lee SH, Lu J (2005). "CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells". Biochem. J. 385 (Pt 1): 85–93. doi:10.1042/BJ20040741. PMC 1134676. PMID 15320871. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1134676.

External links

MeSH CD83+protein,+human

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 (a-c, 1A, 1D, 1E) · CD2 · CD3 (γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 (a) · CD9 · CD10 · CD11 (a, b, c) · CD13 · CD14 · CD15 · CD16 (A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 (A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 (a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 (a, b, c, d, e, f) · CD50

51-100	CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 (E, L, P) · CD63 · CD64 (A, B, C) · CD66 (a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 (a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 (a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD96 · CD97 · CD98 · CD99 · CD100

101-150	CD101 · CD102 · CD103 · CD104 · CD105 · CD106 · CD107 (a, b) · CD108 · CD109 · CD110 · CD111 · CD112 · CD113 · CD114 · CD115 · CD116 · CD117 · CD118 · CD119 · CD120 (a, b) · CD121 (a, b) · CD122 · CD123 · CD124 · CD125 · CD126 · CD127 · CD129 · CD130 · CD131 · CD132 · CD133 · CD134 · CD135 · CD136 · CD137 · CD138 · CD140b · CD141 · CD142 · CD143 · CD144 · CD146 · CD147 · CD148 · CD150

151-200	CD151 · CD152 · CD153 · CD154 · CD155 · CD156 (a, b, c) · CD157 · CD158 (a, d, e, i, k) · CD159 (a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 (a, b) · CD168 · CD169 · CD170 · CD171 · CD172 (a, b, g) · CD174 · CD177 · CD178 · CD179 (a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200

201-250	CD201 · CD202b · CD204 · CD205 · CD206 · CD207 · CD208 · CD209 · CDw210 (a, b) · CD212 · CD213a (1, 2) · CD217 · CD218 (a, b) · CD220 · CD221 · CD222 · CD223 · CD224 · CD225 · CD226 · CD227 · CD228 · CD229 · CD230 · CD233 · CD234 · CD235 (a, b) · CD236 · CD238 · CD239 · CD240CE · CD240D · CD241 · CD243 · CD244 · CD246 · CD247- CD248 · CD249

251-300	CD252 · CD253 · CD254 · CD256 · CD257 · CD258 · CD261 · CD262 · CD264 · CD265 · CD266 · CD267 · CD268 · CD269 · CD271 · CD272 · CD273 · CD274 · CD275 · CD276 · CD278 · CD279 · CD280 · CD281 · CD282 · CD283 · CD284 · CD286 · CD288 · CD289 · CD290 · CD292 · CDw293 · CD294 · CD295 · CD297 · CD298 · CD299

301-350	CD300A · CD301 · CD302 · CD303 · CD304 · CD305 · CD306 · CD307 · CD309 · CD312 · CD314 · CD315 · CD316 · CD317 · CD318 · CD320 · CD321 · CD322 · CD324 · CD325 · CD326 · CD328 · CD329 · CD331 · CD332 · CD333 · CD334 · CD335 · CD336 · CD337 · CD338 · CD339 · CD340 · CD344 · CD349 · CD350

CD83

Contents

See also

References

Further reading

External links