Langerin
CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene.[1][2] Langerin is a type II transmembrane cell surface receptor produced by Langerhans cells.[2][3]
Function
The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.[1]
Clinical significance
Langerin on mucosal Langerhans cells of the human genital epithelium binds to HIV-1 and subsequently internalizes it into Birbeck granules to be degraded.[4][5]
See also
References
- ^ a b "Entrez Gene: CD207 CD207 molecule, langerin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50489.
- ^ a b Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y, Duvert-Frances V, Vincent C, Schmitt D, Davoust J, Caux C, Lebecque S, Saeland S (January 2000). "Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules". Immunity 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407.
- ^ Valladeau J, Clair-Moninot V, Dezutter-Dambuyant C, Pin JJ, Kissenpfennig A, Mattéi MG, Ait-Yahia S, Bates EE, Malissen B, Koch F, Fossiez F, Romani N, Lebecque S, Saeland S (January 2002). "Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues". J. Immunol. 168 (2): 782–92. PMID 11777972. http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=11777972.
- ^ de Witte L, Nabatov A, Pion M, Fluitsma D, de Jong MA, de Gruijl T, Piguet V, van Kooyk Y, Geijtenbeek TB (March 2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nat. Med. 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373.
- ^ Turville S, Wilkinson J, Cameron P, Dable J, Cunningham AL (November 2003). "The role of dendritic cell C-type lectin receptors in HIV pathogenesis". J. Leukoc. Biol. 74 (5): 710–8. doi:10.1189/jlb.0503208. PMID 12960229.
Further reading
- Valladeau J, Dezutter-Dambuyant C, Saeland S (2004). "Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells.". Immunol. Res. 28 (2): 93–107. doi:10.1385/IR:28:2:93. PMID 14610287.
- Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS.". FASEB J. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.
- "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Valladeau J, Ravel O, Dezutter-Dambuyant C, et al. (2000). "Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.". Immunity 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407.
- Turville SG, Cameron PU, Handley A, et al. (2002). "Diversity of receptors binding HIV on dendritic cell subsets.". Nat. Immunol. 3 (10): 975–83. doi:10.1038/ni841. PMID 12352970.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Hunger RE, Sieling PA, Ochoa MT, et al. (2004). "Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.". J. Clin. Invest. 113 (5): 701–8. doi:10.1172/JCI200419655. PMC 351318. PMID 14991068. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=351318.
- Plzáková Z, Chovanec M, Smetana K, et al. (2005). "Comparison of the expression of Langerin and 175 kD mannose receptor in antigen-presenting cells in normal human skin and basal cell carcinoma.". Folia Biol. (Praha) 50 (2): 71–3. doi:10.1007/BF02931296. PMID 15222130.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Verdijk P, Dijkman R, Plasmeijer EI, et al. (2005). "A lack of Birbeck granules in Langerhans cells is associated with a naturally occurring point mutation in the human Langerin gene.". J. Invest. Dermatol. 124 (4): 714–7. doi:10.1111/j.0022-202X.2005.23645.x. PMID 15816828.
- Bousarghin L, Hubert P, Franzen E, et al. (2005). "Human papillomavirus 16 virus-like particles use heparan sulfates to bind dendritic cells and colocalize with langerin in Langerhans cells.". J. Gen. Virol. 86 (Pt 5): 1297–305. doi:10.1099/vir.0.80559-0. PMID 15831940.
- He B, Qiao X, Klasse PJ, et al. (2006). "HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors.". J. Immunol. 176 (7): 3931–41. PMID 16547227.
- Ward EM, Stambach NS, Drickamer K, Taylor ME (2006). "Polymorphisms in human langerin affect stability and sugar binding activity.". J. Biol. Chem. 281 (22): 15450–6. doi:10.1074/jbc.M511502200. PMID 16567809.
- de Witte L, Nabatov A, Pion M, et al. (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells.". Nat. Med. 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373.
- Kaplan DH, Li MO, Jenison MC, et al. (2007). "Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells.". J. Exp. Med. 204 (11): 2545–52. doi:10.1084/jem.20071401. PMC 2118472. PMID 17938236. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2118472.
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