Integrin beta-2 (CD18) is a protein that in humans is encoded by the ITGB2 gene.
It is the beta subunit of four different structures:
The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.[1] In humans lack of CD18 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues.
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CD18 has been shown to interact with ICAM-1,[2][3][4] FHL2,[5] PSCD1[6][7] and GNB2L1.[8]
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