| Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | |
|---|---|
| Identifiers | |
| Symbol | FCGR3A |
| Alt. symbols | FCGR3, FCG3 |
| Entrez | 2214 |
| HUGO | 3619 |
| OMIM | 146740 |
| RefSeq | NM_000569 |
| UniProt | P08637 |
| Other data | |
| Locus | Chr. 1 q23 |
| Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | |
|---|---|
| Identifiers | |
| Symbol | FCGR3B |
| Alt. symbols | FCGR3, FCG3 |
| Entrez | 2215 |
| HUGO | 3620 |
| OMIM | 610665 |
| RefSeq | NM_000570 |
| UniProt | O75015 |
| Other data | |
| Locus | Chr. 1 q23 |
CD16 is a low affinity Fc receptor.
It is a cluster of differentiation found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages[1]. It can be used to isolate populations of these cells by antibodies directed towards CD16, utilising FACS (fluorescent-activated cell sorting) or MACS (magnetic-activated cell sorting).
CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies.
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