SLAMF1

Signaling lymphocytic activation molecule family member 1

Rendering of SLAMF1 from PDB 1D4T

Available structures
PDB	1D4T, 1D4W, 1KA6, 1KA7, 1M27, 2DZF, 2IE9, 2IFL, 2IG5

Identifiers

Symbols

SLAMF1; CD150; CDw150; SLAM

External IDs

OMIM: 603492 MGI: 1351314 HomoloGene: 48162 GeneCards: SLAMF1 Gene

Gene Ontology
Molecular function	• antigen binding • transmembrane receptor activity
Cellular component	• plasma membrane • external side of plasma membrane • integral to membrane
Biological process	• positive regulation of cell proliferation • interspecies interaction between organisms • lymphocyte activation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
160.58 – 160.62 Mb

Chr 1:
173.7 – 173.73 Mb

PubMed search

[1]

[2]

Signaling lymphocytic activation molecule is a protein that in humans is encoded by the SLAMF1 gene.^[1]^[2]

SLAMF1 has also recently has been designated CD150 (cluster of differentiation 150).

Interactions

SLAMF1 has been shown to interact with PTPN11,^[3]^[4] SH2D1A^[3]^[5] and SH2D1B.^[4]

References

^ Cocks BG, Chang CC, Carballido JM, Yssel H, de Vries JE, Aversa G (Aug 1995). "A novel receptor involved in T-cell activation". Nature 376 (6537): 260–3. doi:10.1038/376260a0. PMID 7617038.
^ "Entrez Gene: SLAMF1 signaling lymphocytic activation molecule family member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6504.
^ ^a ^b Howie, Duncan; Simarro María, Sayos Joan, Guirado Maria, Sancho Jaime, Terhorst Cox (Feb. 2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation". Blood (United States) 99 (3): 957–65. doi:10.1182/blood.V99.3.957. ISSN 0006-4971. PMID 11806999.
^ ^a ^b Morra, M; Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle A J, Denny C, Yaffe M B, Engel P, Eck M J, Terhorst C (Nov. 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. (England) 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. ISSN 0261-4189. PMC 125701. PMID 11689425. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125701.
^ Morra, M; Simarro-Grande M, Martin M, Chen A S, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck M J, Sumegi J, Engel P, Li S C, Terhorst C (Sep. 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. (United States) 276 (39): 36809–16. doi:10.1074/jbc.M101305200. ISSN 0021-9258. PMID 11477068.

Punnonen J, Cocks BG, Carballido JM, et al. (1997). "Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes.". J. Exp. Med. 185 (6): 993–1004. doi:10.1084/jem.185.6.993. PMC 2196230. PMID 9091591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2196230.
Sayos J, Wu C, Morra M, et al. (1998). "The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.". Nature 395 (6701): 462–9. doi:10.1038/26683. PMID 9774102.
Mikhalap SV, Shlapatska LM, Berdova AG, et al. (1999). "CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis.". J. Immunol. 162 (10): 5719–27. PMID 10229804.
Li SC, Gish G, Yang D, et al. (2000). "Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A.". Curr. Biol. 9 (23): 1355–62. doi:10.1016/S0960-9822(00)80080-9. PMID 10607564.
Rogge L, Bianchi E, Biffi M, et al. (2000). "Transcript imaging of the development of human T helper cells using oligonucleotide arrays.". Nat. Genet. 25 (1): 96–101. doi:10.1038/75671. PMID 10802665.
Tatsuo H, Ono N, Tanaka K, Yanagi Y (2000). "SLAM (CDw150) is a cellular receptor for measles virus.". Nature 406 (6798): 893–7. doi:10.1038/35022579. PMID 10972291.
Lewis J, Eiben LJ, Nelson DL, et al. (2001). "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.". Clin. Immunol. 100 (1): 15–23. doi:10.1006/clim.2001.5035. PMID 11414741.
Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.". J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.
Kruse M, Meinl E, Henning G, et al. (2001). "Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta.". J. Immunol. 167 (4): 1989–95. PMID 11489980.
Bleharski JR, Niazi KR, Sieling PA, et al. (2001). "Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines.". J. Immunol. 167 (6): 3174–81. PMID 11544303.
Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125701.
Howie D, Simarro M, Sayos J, et al. (2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation.". Blood 99 (3): 957–65. doi:10.1182/blood.V99.3.957. PMID 11806999.
Murabayashi N, Kurita-Taniguchi M, Ayata M, et al. (2002). "Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification.". Microbes Infect. 4 (8): 785–94. doi:10.1016/S1286-4579(02)01598-8. PMID 12270725.
Li C, Iosef C, Jia CY, et al. (2003). "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors.". J. Biol. Chem. 278 (6): 3852–9. doi:10.1074/jbc.M206649200. PMID 12458214.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Hahm B, Arbour N, Naniche D, et al. (2003). "Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule.". J. Virol. 77 (6): 3505–15. doi:10.1128/JVI.77.6.3505-3515.2003. PMC 149525. PMID 12610126. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149525.
Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2).". J. Biol. Chem. 278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID 12621057.
Ferrand V, Li C, Romeo G, Yin L (2003). "Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients.". J. Med. Virol. 70 (1): 131–6. doi:10.1002/jmv.10373. PMID 12629654.
Laaksonen K, Junikka M, Lahesmaa R, et al. (2004). "In vitro allergen-induced mRNA expression of signaling lymphocytic activation molecule by PBMC of patients with allergic rhinitis is increased during specific pollen immunotherapy.". J. Allergy Clin. Immunol. 112 (6): 1171–7. doi:10.1016/j.jaci.2003.08.043. PMID 14657878.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 (a-c, 1A, 1D, 1E) · CD2 · CD3 (γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 (a) · CD9 · CD10 · CD11 (a, b, c) · CD13 · CD14 · CD15 · CD16 (A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 (A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 (a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 (a, b, c, d, e, f) · CD50

51-100	CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 (E, L, P) · CD63 · CD64 (A, B, C) · CD66 (a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 (a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 (a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD96 · CD97 · CD98 · CD99 · CD100

101-150	CD101 · CD102 · CD103 · CD104 · CD105 · CD106 · CD107 (a, b) · CD108 · CD109 · CD110 · CD111 · CD112 · CD113 · CD114 · CD115 · CD116 · CD117 · CD118 · CD119 · CD120 (a, b) · CD121 (a, b) · CD122 · CD123 · CD124 · CD125 · CD126 · CD127 · CD129 · CD130 · CD131 · CD132 · CD133 · CD134 · CD135 · CD136 · CD137 · CD138 · CD140b · CD141 · CD142 · CD143 · CD144 · CD146 · CD147 · CD148 · CD150

151-200	CD151 · CD152 · CD153 · CD154 · CD155 · CD156 (a, b, c) · CD157 · CD158 (a, d, e, i, k) · CD159 (a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 (a, b) · CD168 · CD169 · CD170 · CD171 · CD172 (a, b, g) · CD174 · CD177 · CD178 · CD179 (a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200

201-250	CD201 · CD202b · CD204 · CD205 · CD206 · CD207 · CD208 · CD209 · CDw210 (a, b) · CD212 · CD213a (1, 2) · CD217 · CD218 (a, b) · CD220 · CD221 · CD222 · CD223 · CD224 · CD225 · CD226 · CD227 · CD228 · CD229 · CD230 · CD233 · CD234 · CD235 (a, b) · CD236 · CD238 · CD239 · CD240CE · CD240D · CD241 · CD243 · CD244 · CD246 · CD247- CD248 · CD249

251-300	CD252 · CD253 · CD254 · CD256 · CD257 · CD258 · CD261 · CD262 · CD264 · CD265 · CD266 · CD267 · CD268 · CD269 · CD271 · CD272 · CD273 · CD274 · CD275 · CD276 · CD278 · CD279 · CD280 · CD281 · CD282 · CD283 · CD284 · CD286 · CD288 · CD289 · CD290 · CD292 · CDw293 · CD294 · CD295 · CD297 · CD298 · CD299

301-350	CD300A · CD301 · CD302 · CD303 · CD304 · CD305 · CD306 · CD307 · CD309 · CD312 · CD314 · CD315 · CD316 · CD317 · CD318 · CD320 · CD321 · CD322 · CD324 · CD325 · CD326 · CD328 · CD329 · CD331 · CD332 · CD333 · CD334 · CD335 · CD336 · CD337 · CD338 · CD339 · CD340 · CD344 · CD349 · CD350

SLAMF1

Interactions

References

Further reading