CCR2, short for chemokine (C-C motif) receptor 2, is a chemokine receptor.
CCR2 has also recently been designated CD192 (cluster of differentiation 192).
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.[1]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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