CCNDBP1

Cyclin D-type binding-protein 1
Identifiers
Symbols CCNDBP1; DIP1; GCIP
External IDs OMIM607089 MGI109595 HomoloGene7826 GeneCards: CCNDBP1 Gene
Orthologs
Species Human Mouse
Entrez 23582 17151
Ensembl ENSG00000166946 ENSMUSG00000023572
UniProt O95273 n/a
RefSeq (mRNA) NM_012142.3 NM_010761.2
RefSeq (protein) NP_036274.3 NP_034891.2
Location (UCSC) Chr 15:
43.48 – 43.49 Mb
Chr 2:
120.83 – 120.84 Mb
PubMed search [1] [2]

Cyclin-D1-binding protein 1 is a protein that in humans is encoded by the CCNDBP1 gene.[1][2]

This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.[2]

Interactions

CCNDBP1 has been shown to interact with GRAP2[1] and Cyclin D1.[1]

References

  1. ^ a b c Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Aug 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". J Biol Chem 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID 10801854. 
  2. ^ a b "Entrez Gene: CCNDBP1 cyclin D-type binding-protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23582. 

Further reading