| Chemokine (C-C motif) ligand 12 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | Ccl12; MCP-5; Scya12 | ||||||||||||
| External IDs | MGI: 108224 HomoloGene: 2245 GeneCards: Ccl12 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 20293 | 20293 | |||||||||||
| Ensembl | ENSMUSG00000035352 | ENSMUSG00000035352 | |||||||||||
| UniProt | Q62401 | Q5SVB4 | |||||||||||
| RefSeq (mRNA) | n/a | NM_011331.2 | |||||||||||
| RefSeq (protein) | n/a | NP_035461.2 | |||||||||||
| Location (UCSC) | Chr 11: 81.92 – 81.92 Mb |
Chr 11: 81.92 – 81.92 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been described in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine. CCL12 specifically attracts eosinophils, monocytes and lymphocytes.[1] This chemokine is found predominately in lymph nodes and thymus under normal conditions, and its expression can be hugely induced in macrophages.[1][2] It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on mouse chromosome 11.[2]
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