CCBP2

Chemokine binding protein 2

Identifiers

CCBP2; CCR10; CCR9; CMKBR9; D6; MGC126678; MGC138250; hD6

External IDs

OMIM: 602648 MGI: 1891697 HomoloGene: 992 IUPHAR: CCPB2 GeneCards: CCBP2 Gene

Gene Ontology
Molecular function	• receptor activity • G-protein coupled receptor activity • chemokine receptor activity • C-C chemokine receptor activity • C-X-C chemokine receptor activity
Cellular component	• plasma membrane • integral to plasma membrane
Biological process	• chemotaxis • immune response • G-protein coupled receptor protein signaling pathway • multicellular organismal development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
42.85 – 42.95 Mb

Chr 9:
121.81 – 121.82 Mb

PubMed search

[1]

[2]

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.^[1]^[2]^[3]

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.^[3]

References

^ Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF (Dec 1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936.
^ Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ (Jan 1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". J Biol Chem 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404.
^ ^a ^b "Entrez Gene: CCBP2 chemokine binding protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1238.

Nibbs RJ, Wylie SM, Pragnell IB, Graham GJ (1997). "Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5.". J. Biol. Chem. 272 (19): 12495–504. doi:10.1074/jbc.272.19.12495. PMID 9139699.
Nibbs RJ, Yang J, Landau NR, et al. (1999). "LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity.". J. Biol. Chem. 274 (25): 17478–83. doi:10.1074/jbc.274.25.17478. PMID 10364178.
Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.". Cytogenet. Cell Genet. 87 (3-4): 265–8. doi:10.1159/000015443. PMID 10702689.
Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK.". J. Immunol. 164 (6): 2851–6. PMID 10706668.
Jarmin DI, Rits M, Bota D, et al. (2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine.". J. Immunol. 164 (7): 3460–4. PMID 10725696.
Homey B, Wang W, Soto H, et al. (2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).". J. Immunol. 164 (7): 3465–70. PMID 10725697.
Wang W, Soto H, Oldham ER, et al. (2000). "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).". J. Biol. Chem. 275 (29): 22313–23. doi:10.1074/jbc.M001461200. PMID 10781587.
Nibbs RJ, Kriehuber E, Ponath PD, et al. (2001). "The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors.". Am. J. Pathol. 158 (3): 867–77. PMC 1850343. PMID 11238036. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850343.
Homey B, Alenius H, Müller A, et al. (2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation.". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900.
Soler D, Humphreys TL, Spinola SM, Campbell JJ (2003). "CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking.". Blood 101 (5): 1677–82. doi:10.1182/blood-2002-07-2348. PMID 12406880.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Fra AM, Locati M, Otero K, et al. (2003). "Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6.". J. Immunol. 170 (5): 2279–82. PMID 12594248.
Kunkel EJ, Kim CH, Lazarus NH, et al. (2003). "CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells.". J. Clin. Invest. 111 (7): 1001–10. doi:10.1172/JCI17244. PMC 152588. PMID 12671049. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152588.
Galliera E, Jala VR, Trent JO, et al. (2004). "beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.". J. Biol. Chem. 279 (24): 25590–7. doi:10.1074/jbc.M400363200. PMID 15084596.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Neil SJ, Aasa-Chapman MM, Clapham PR, et al. (2005). "The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes.". J. Virol. 79 (15): 9618–24. doi:10.1128/JVI.79.15.9618-9624.2005. PMC 1181543. PMID 16014924. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1181543.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cytokine receptors

Chemokine receptor
(GPCRs)

CC	CCR1/CCRL1 · CCR2 · CCRL2 · CCR3 · CCR4 · CCR5 · CCR6 · CCR7 · CCR8 · CCR9 · CCR10

CXC	IL-8 (CXCR1, CXCR2) · CXCR3 · CXCR4 · CXCR5 · CXCR6 · CXCR7

Other	CX3C (CX3CR1) · XC (XCR1) · CCBP2 · CMKLR1

TNF receptor

1-10	TNFRSF1 (CD120) · TNFRSF1A (CD120a) · TNFRSF1B (CD120b) · TNFRSF3 (Lymphotoxin beta receptor) · TNFRSF4 (CD134) · TNFRSF5 (CD40) · TNFRSF6 (FAS) · TNFRSF6B · TNFRSF7 (CD27) · TNFRSF8 (CD30) · TNFRSF9 (CD137)

11-20	TNFRSF10A (CD261) · TNFRSF10B (CD262) · TNFRSF10C (CD263) · TNFRSF10D (CD264) · TNFRSF11A (CD265/RANK) · TNFRSF11B (Osteoprotegerin) · TNFRSF12A (CD266) · TNFRSF13B (CD267) · TNFRSF13C · TNFRSF14 (CD268) · TNFRSF16 (Nerve growth factor receptor) · TNFRSF17 (CD269) · TNFRSF18 · TNFRSF19

21-25	TNFRSF21 · TNFRSF25 · TNFRSF27

JAK-STAT

Type I

γ-chain	Interleukin receptors (IL2R/IL2RA/IL2RB/IL15R, IL4R/IL13R/IL13RA1/IL13RA2, IL7R/IL7RA, IL9R, IL21R)

β-chain	Interleukin receptors (IL3R/IL3RA, IL5R/IL5RA) · GM-CSF

gp130	Interleukin receptors (IL6RA, 11/IL11RA, 27/IL27RA) · OSMR · LIFR · CNTFR

IL12RB1	Interleukin receptors (IL12R/IL12RB1/IL12RB2, IL23R23)

Other	other CSF receptors (EPO, G-CSF, Thrombopoietin) hormone receptor: GH · prolactin

Type II

Interleukin receptors (IL10R/IL10RA/IL10RB/IL22R/IL22RA2, IL20R/IL20RA/IL20RB, IL28R) · Interferon receptors (-α/β/IFNAR1/IFNAR2, -γ/IFNGR1/IFNGR2)

Ig superfamily

CSF1 · KIT · IL1 (IL1R1, IL1R2) · IL18R/IL18R1

IL-17 family

IL-17 (IL17RA, IL17RB, IL17RC, IL17RD, IL17RE)

S/T

TGF-beta (TGFBR1, TGFBR2)

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

CCBP2

References

Further reading