CAND1
Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene.[1][2][3]
Interactions
CAND1 has been shown to interact with CUL4A,[4] CUL4B,[4] RBX1,[4][5] CUL1,[4][6] DCUN1D1,[5] CUL3[4] and CUL2.[4][6]
References
- ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
- ^ Yogosawa S, Makino Y, Yoshida T, Kishimoto T, Muramatsu M, Tamura T (Jan 1997). "Molecular cloning of a novel 120-kDa TBP-interacting protein". Biochem Biophys Res Commun 229 (2): 612–7. doi:10.1006/bbrc.1996.1852. PMID 8954946.
- ^ "Entrez Gene: CAND1 cullin-associated and neddylation-dissociated 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55832.
- ^ a b c d e f Min, Kyoeng-Woo; Hwang Ji-Won, Lee Jong-Sik, Park Yoon, Tamura Taka-aki, Yoon Jong-Bok (May. 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". J. Biol. Chem. (United States) 278 (18): 15905–10. doi:10.1074/jbc.M213070200. ISSN 0021-9258. PMID 12609982.
- ^ a b Kim, Alexander Y; Bommeljé Claire C, Lee Benjamin E, Yonekawa Yoshihiro, Choi Lydia, Morris Luc G, Huang Guochang, Kaufman Andrew, Ryan Russel J H, Hao Bing, Ramanathan Y, Singh Bhuvanesh (Nov. 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". J. Biol. Chem. (United States) 283 (48): 33211–20. doi:10.1074/jbc.M804440200. ISSN 0021-9258. PMC 2586271. PMID 18826954. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2586271.
- ^ a b Menon, Suchithra; Tsuge Tomohiko, Dohmae Naoshi, Takio Koji, Wei Ning (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochem. (England) 9: 1. doi:10.1186/1471-2091-9-1. PMC 2265268. PMID 18173839. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2265268.
Further reading
- Yogosawa S, Kayukawa K, Kawata T, et al. (2000). "Induced expression, localization, and chromosome mapping of a gene for the TBP-interacting protein 120A.". Biochem. Biophys. Res. Commun. 266 (1): 123–8. doi:10.1006/bbrc.1999.1773. PMID 10581176.
- Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16901.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Liu J, Furukawa M, Matsumoto T, Xiong Y (2003). "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.". Mol. Cell 10 (6): 1511–8. doi:10.1016/S1097-2765(02)00783-9. PMID 12504025.
- Zheng J, Yang X, Harrell JM, et al. (2003). "CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.". Mol. Cell 10 (6): 1519–26. doi:10.1016/S1097-2765(02)00784-0. PMID 12504026.
- Min KW, Hwang JW, Lee JS, et al. (2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity.". J. Biol. Chem. 278 (18): 15905–10. doi:10.1074/jbc.M213070200. PMID 12609982.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Feng S, Shen Y, Sullivan JA, et al. (2004). "Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation.". Plant Cell 16 (7): 1870–82. doi:10.1105/tpc.021949. PMC 514167. PMID 15208391. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514167.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Goldenberg SJ, Cascio TC, Shumway SD, et al. (2004). "Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.". Cell 119 (4): 517–28. doi:10.1016/j.cell.2004.10.019. PMID 15537541.
- Min KW, Kwon MJ, Park HS, et al. (2006). "CAND1 enhances deneddylation of CUL1 by COP9 signalosome.". Biochem. Biophys. Res. Commun. 334 (3): 867–74. doi:10.1016/j.bbrc.2005.06.188. PMID 16036220.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
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PDB gallery
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1u6g: Crystal Structure of The Cand1-Cul1-Roc1 Complex
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