Calmodulin 1
| Calmodulin 1 (phosphorylase kinase, delta) |
PDB rendering based on 1a29. |
| Available structures |
| PDB |
1AJI, 1CDL, 1CLL, 1CTR, 1IWQ, 1J7O, 1J7P, 1K90, 1K93, 1L7Z, 1LVC, 1NKF, 1PK0, 1S26, 1SK6, 1SW8, 1WRZ, 1XFU, 1XFV, 1XFW, 1XFX, 1XFY, 1XFZ, 1Y6W, 1YR5, 1YRT, 1YRU, 1ZOT, 1ZUZ, 2BE6, 2F3Y, 2F3Z, 2HF5, 2I08, 2JZI, 2K0E, 2K0F, 2K0J, 2K61, 2KNE, 2KUG, 2KUH, 2R28, 2V01, 2V02, 2VAY, 2W73, 2WEL, 2X0G, 3BYA, 3DVE, 3DVJ, 3DVK, 3DVM, 3EWT, 3EWV, 3G43, 3HR4, 3O77, 3O78, 3OXQ |
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| Identifiers |
| Symbols |
CALM1; CALM2; CALM3; CALML2; CAMI; DD132; PHKD; caM |
| External IDs |
OMIM: 114180 MGI: 88251 HomoloGene: 111276 GeneCards: CALM1 Gene |
| EC number |
2.7.11.19 |
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| Orthologs |
| Species |
Human |
Mouse |
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| Entrez |
801 |
640703 |
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| Ensembl |
ENSG00000198668 |
ENSMUSG00000001175 |
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| UniProt |
P62158 |
P62204 |
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| RefSeq (mRNA) |
NM_001166106.1 |
NM_009790 |
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| RefSeq (protein) |
NP_001159578.1 |
NP_033920 |
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| Location (UCSC) |
Chr 14:
90.86 – 90.87 Mb |
Chr 12:
101.44 – 101.45 Mb |
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| PubMed search |
[1] |
[2] |
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Calmodulin 1 is a protein that in humans is encoded by the CALM1 gene.[1]
Function
Calmodulin 1 is the archetype of the family of calcium-modulated (calmodulin) proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 148 amino acids and has 4 calcium-binding motifs. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.[2]
Interactions
Calmodulin 1 has been shown to interact with AKAP9,[3] TRPV1,[4] Androgen receptor,[5] IQGAP1[6][7] and PPEF1.[8]
References
- ^ Wawrzynczak EJ, Perham RN (August 1984). "Isolation and nucleotide sequence of a cDNA encoding human calmodulin". Biochem. Int. 9 (2): 177–85. PMID 6385987.
- ^ "Entrez Gene: CALM1 calmodulin 1 (phosphorylase kinase, delta)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=801.
- ^ Takahashi, Mikiko; Yamagiwa Akiko, Nishimura Tamako, Mukai Hideyuki, Ono Yoshitaka (Sep. 2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell (United States) 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. ISSN 1059-1524. PMC 124155. PMID 12221128. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124155.
- ^ Numazaki, Mitsuko; Tominaga Tomoko, Takeuchi Kumiko, Murayama Namie, Toyooka Hidenori, Tominaga Makoto (Jun. 2003). "Structural determinant of TRPV1 desensitization interacts with calmodulin". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (13): 8002–6. doi:10.1073/pnas.1337252100. ISSN 0027-8424. PMC 164702. PMID 12808128. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164702.
- ^ Cifuentes, Eugenia; Mataraza Jennifer M, Yoshida Barbara A, Menon Mani, Sacks David B, Barrack Evelyn R, Reddy G Prem-Veer (Jan. 2004). "Physical and functional interaction of androgen receptor with calmodulin in prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (2): 464–9. doi:10.1073/pnas.0307161101. ISSN 0027-8424. PMC 327170. PMID 14695896. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=327170.
- ^ Li, Zhigang; Sacks David B (Feb. 2003). "Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1". J. Biol. Chem. (United States) 278 (6): 4347–52. doi:10.1074/jbc.M208579200. ISSN 0021-9258. PMID 12446675.
- ^ Briggs, Michael W; Li Zhigang, Sacks David B (Mar. 2002). "IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin". J. Biol. Chem. (United States) 277 (9): 7453–65. doi:10.1074/jbc.M104315200. ISSN 0021-9258. PMID 11734550.
- ^ Kutuzov, Mikhail A; Solov'eva Olga V, Andreeva Alexandra V, Bennett Nelly (May. 2002). "Protein Ser/Thr phosphatases PPEF interact with calmodulin". Biochem. Biophys. Res. Commun. (United States) 293 (3): 1047–52. doi:10.1016/S0006-291X(02)00338-8. ISSN 0006-291X. PMID 12051765.
Further reading
- Zhang M, Yuan T (1999). "Molecular mechanisms of calmodulin's functional versatility". Biochem. Cell Biol. 76 (2–3): 313–23. doi:10.1139/bcb-76-2-3-313. PMID 9923700.
- Gusev NB (2002). "Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation". Biochemistry Mosc. 66 (10): 1112–21. doi:10.1023/A:1012480829618. PMID 11736632.
- Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications". Eur. J. Biochem. 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. PMID 12153558.
- Trudeau MC, Zagotta WN (2003). "Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels". J. Biol. Chem. 278 (21): 18705–8. doi:10.1074/jbc.R300001200. PMID 12626507.
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PDB gallery
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1a29: CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:2 COMPLEX)
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1ahr: CALMODULIN MUTANT WITH A TWO RESIDUE DELETION IN THE CENTRAL HELIX
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1ak8: NMR SOLUTION STRUCTURE OF CERIUM-LOADED CALMODULIN AMINO-TERMINAL DOMAIN (CE2-TR1C), 23 STRUCTURES
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1cdl: TARGET ENZYME RECOGNITION BY CALMODULIN: 2.4 ANGSTROMS STRUCTURE OF A CALMODULIN-PEPTIDE COMPLEX
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1cdm: MODULATION OF CALMODULIN PLASTICITY IN MOLECULAR RECOGNITION ON THE BASIS OF X-RAY STRUCTURES
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1cfc: CALCIUM-FREE CALMODULIN
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1cfd: CALCIUM-FREE CALMODULIN
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1cff: NMR SOLUTION STRUCTURE OF A COMPLEX OF CALMODULIN WITH A BINDING PEPTIDE OF THE CA2+-PUMP
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1ckk: CALMODULIN/RAT CA2+/CALMODULIN DEPENDENT PROTEIN KINASE FRAGMENT
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1cll: CALMODULIN STRUCTURE REFINED AT 1.7 ANGSTROMS RESOLUTION
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1cm1: MOTIONS OF CALMODULIN-SINGLE-CONFORMER REFINEMENT
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1cm4: MOTIONS OF CALMODULIN-FOUR-CONFORMER REFINEMENT
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1cmf: NMR SOLUTION STRUCTURE OF APO CALMODULIN CARBOXY-TERMINAL DOMAIN
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1cmg: NMR SOLUTION STRUCTURE OF CALCIUM-LOADED CALMODULIN CARBOXY-TERMINAL DOMAIN
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1ctr: DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX
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1deg: THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE
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1dmo: CALMODULIN, NMR, 30 STRUCTURES
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1f70: REFINED SOLUTION STRUCTURE OF CALMODULIN N-TERMINAL DOMAIN
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1f71: REFINED SOLUTION STRUCTURE OF CALMODULIN C-TERMINAL DOMAIN
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1fw4: CRYSTAL STRUCTURE OF E. COLI FRAGMENT TR2C FROM CALMODULIN TO 1.7 A RESOLUTION
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1g4y: 1.60 A CRYSTAL STRUCTURE OF THE GATING DOMAIN FROM SMALL CONDUCTANCE POTASSIUM CHANNEL COMPLEXED WITH CALCIUM-CALMODULIN
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1iq5: Calmodulin/nematode CA2+/Calmodulin dependent kinase kinase fragment
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1iwq: Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin
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1j7o: Solution structure of Calcium-calmodulin N-terminal domain
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1j7p: Solution structure of Calcium calmodulin C-terminal domain
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1k90: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
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1k93: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin
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1l7z: Crystal structure of Ca2+/Calmodulin complexed with myristoylated CAP-23/NAP-22 peptide
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1lin: CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:4 COMPLEX)
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1lvc: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP
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1mux: SOLUTION NMR STRUCTURE OF CALMODULIN/W-7 COMPLEX: THE BASIS OF DIVERSITY IN MOLECULAR RECOGNITION, 30 STRUCTURES
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1mxe: Structure of the Complex of Calmodulin with the Target Sequence of CaMKI
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1niw: Crystal structure of endothelial nitric oxide synthase peptide bound to calmodulin
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1nwd: Solution Structure of Ca2+/Calmodulin bound to the C-terminal Domain of Petunia Glutamate Decarboxylase
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1ooj: Structural genomics of Caenorhabditis elegans : Calmodulin
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1pk0: Crystal Structure of the EF3-CaM complexed with PMEApp
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1prw: Crystal structure of bovine brain Ca++ calmodulin in a compact form
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1qiv: CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD), 1:2 COMPLEX
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1qiw: CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD)
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1qs7: The 1.8 angstrom structure of calmodulin rs20 peptide complex
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1qtx: THE 1.65 ANGSTROM STRUCTURE OF CALMODULIN RS20 PEPTIDE COMPLEX
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1qx5: Crystal structure of apoCalmodulin
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1qx7: Crystal structure of apoCaM bound to the gating domain of small conductance Ca2+-activated potassium channel
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1s26: Structure of Anthrax Edema Factor-Calmodulin-alpha,beta-methyleneadenosine 5'-triphosphate Complex Reveals an Alternative Mode of ATP Binding to the Catalytic Site
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1sk6: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate
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1sw8: Solution structure of the N-terminal domain of Human N60D calmodulin refined with paramagnetism based strategy
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1sy9: Structure of calmodulin complexed with a fragment of the olfactory CNG channel
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1vrk: THE 1.9 ANGSTROM STRUCTURE OF E84K-CALMODULIN RS20 PEPTIDE COMPLEX
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1wrz: Calmodulin complexed with a peptide from a human death-associated protein kinase
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1x02: Solution structure of stereo array isotope labeled (SAIL) calmodulin
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1xa5: Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid
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1xfu: Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin
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1xfv: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
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1xfw: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP)
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1xfx: Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride
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1xfy: Crystal structure of anthrax edema factor (EF) in complex with calmodulin
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1xfz: Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride
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1y0v: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate
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1y6w: Trapped intermediate of calmodulin
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1yr5: 1.7-A structure of calmodulin bound to a peptide from DAP kinase
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1yrt: Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin
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1yru: Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin and 1mM calcium chloride
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1zot: crystal structure analysis of the CyaA/C-Cam with PMEAPP
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1zuz: Calmodulin in complex with a mutant peptide from human DRP-1 kinase
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2bbm: SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR
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2bbn: SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR
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2bcx: Crystal structure of calmodulin in complex with a ryanodine receptor peptide
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2be6: 2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex
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2bkh: MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2) CRYSTAL STRUCTURE
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2bki: MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2-IQ) CRYSTAL STRUCTURE
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2col: Crystal structure analysis of CyaA/C-Cam with Pyrophosphate
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2dfs: 3-D structure of Myosin-V inhibited state
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2f2o: Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
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2f2p: Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
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2f3y: Calmodulin/IQ domain complex
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2f3z: Calmodulin/IQ-AA domain complex
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2fot: Crystal structure of the complex between calmodulin and alphaII-spectrin
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2hf5: The structure and function of a novel two-site calcium-binding fragment of calmodulin
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2ix7: STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V
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3cln: STRUCTURE OF CALMODULIN REFINED AT 2.2 ANGSTROMS RESOLUTION
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4cln: STRUCTURE OF A RECOMBINANT CALMODULIN FROM DROSOPHILA MELANOGASTER REFINED AT 2.2-ANGSTROMS RESOLUTION
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External links