Calcium channel, voltage-dependent, alpha 2/delta subunit 2 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | CACNA2D2; CACNA2D; KIAA0558; LUAC11.1 | ||||||||||||
External IDs | OMIM: 607082 MGI: 1929813 HomoloGene: 4400 GeneCards: CACNA2D2 Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 9254 | 56808 | |||||||||||
Ensembl | ENSG00000007402 | ENSMUSG00000010066 | |||||||||||
UniProt | Q9NY47 | n/a | |||||||||||
RefSeq (mRNA) | NM_001005505.1 | XM_980539 | |||||||||||
RefSeq (protein) | NP_001005505.1 | XP_985633 | |||||||||||
Location (UCSC) | Chr 3: 50.4 – 50.54 Mb |
Chr 9: 107.3 – 107.43 Mb |
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PubMed search | [1] | [2] |
Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.[1]
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[1]
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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