CA11
Carbonic anhydrase-related protein 11 is an enzyme that in humans is encoded by the CA11 gene.[1][2]
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system.[2]
Interactions
CA11 has been shown to interact with RIPK1.[3]
References
- ^ Lovejoy DA, Hewett-Emmett D, Porter CA, Cepoi D, Sheffield A, Vale WW, Tashian RE (Feb 1999). "Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3". Genomics 54 (3): 484–93. doi:10.1006/geno.1998.5585. PMID 9878252.
- ^ a b "Entrez Gene: CA11 carbonic anhydrase XI". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=770.
- ^ Liao, Wentao; Xiao Qi, Tchikov Vladimir, Fujita Ken-ichi, Yang Wensheng, Wincovitch Stephen, Garfield Susan, Conze Dietrich, El-Deiry Wafik S, Schütze Stefan, Srinivasula Srinivasa M (May. 2008). "CARP-2 is an endosome-associated ubiquitin protein ligase for RIP and regulates TNF-induced NF-κB activation". Curr. Biol. (England) 18 (9): 641–9. doi:10.1016/j.cub.2008.04.017. ISSN 0960-9822. PMC 2587165. PMID 18450452. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2587165.
Further reading
- Bellingham J, Gregory-Evans K, Gregory-Evans CY (1999). "Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3". Biochem. Biophys. Res. Commun. 253 (2): 364–7. doi:10.1006/bbrc.1998.9449. PMID 9878543.
- Fujikawa-Adachi K, Nishimori I, Taguchi T, et al. (1999). "cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI". Biochim. Biophys. Acta 1431 (2): 518–24. doi:10.1016/S0167-4838(99)00067-9. PMID 10350627.
- Okamoto N, Fujikawa-Adachi K, Nishimori I, et al. (2001). "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain". Biochim. Biophys. Acta 1518 (3): 311–6. PMID 11311946.
- Taniuchi K, Nishimori I, Takeuchi T, et al. (2002). "Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain". Neuroscience 112 (1): 93–9. doi:10.1016/S0306-4522(02)00066-0. PMID 12044474.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850943.