C3orf15

Chromosome 3 open reading frame 15

Identifiers

C3orf15; AAT1; AAT1alpha; DKFZp781A2221

External IDs

OMIM: 609910 MGI: 2443598 HomoloGene: 33470 GeneCards: C3orf15 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• cytoplasm • mitochondrion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000183833

ENSMUSG00000022805

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
119.42 – 119.49 Mb

Chr 16:
38.3 – 38.34 Mb

PubMed search

AMY-1-associating protein expressed in testis 1 is a protein that in humans is encoded by the C3orf15 gene.^[1]^[2]^[3]

Interactions

C3orf15 has been shown to interact with MYCBP ^[1] and AKAP1 .^[1]

References

^ ^a ^b ^c Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J Biol Chem 277 (47): 45480–92. doi:10.1074/jbc.M206201200. PMID 12223483.
^ Hayes VM, Gardiner-Garden M (Oct 2003). "Are polymorphic markers within the alpha-1-antitrypsin gene associated with risk of human immunodeficiency virus disease?". J Infect Dis 188 (8): 1205–8. doi:10.1086/378641. PMID 14551891.
^ "Entrez Gene: C3orf15 chromosome 3 open reading frame 15". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89876.

Further reading

Matsuda E, Ishizaki R, Taira T, et al. (2005). "Structure and characterization of AAT-1 isoforms.". Biol. Pharm. Bull. 28 (5): 898–901. doi:10.1248/bpb.28.898. PMID 15863901.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Talmud PJ, Martin S, Steiner G, et al. (2004). "Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin gene.". Arterioscler. Thromb. Vasc. Biol. 23 (4): 644–9. doi:10.1161/01.ATV.0000065196.61663.8D. PMID 12692006.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Mashiba S, Wada Y, Takeya M, et al. (2001). "In vivo complex formation of oxidized alpha(1)-antitrypsin and LDL". Arterioscler. Thromb. Vasc. Biol. 21 (11): 1801–8. doi:10.1161/hq1101.098232. PMID 11701469.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.