C1D
Nuclear nucleic acid-binding protein C1D is a protein that in humans is encoded by the C1D gene.[1][2][3][4][5][6]
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined.[6]
Interactions
C1D has been shown to interact with TSNAX[4] and DNA-PKcs.[7]
References
- ^ Nehls P, Keck T, Greferath R, Spiess E, Glaser T, Rothbarth K, Stammer H, Werner D (Apr 1998). "cDNA cloning, recombinant expression and characterization of polypetides with exceptional DNA affinity". Nucleic Acids Res 26 (5): 1160–6. doi:10.1093/nar/26.5.1160. PMC 147382. PMID 9469821. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=147382.
- ^ Schilders G, Egberts WV, Raijmakers R, Pruijn GJ (Jul 2007). "C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome". Arthritis Rheum 56 (7): 2449–54. doi:10.1002/art.22710. PMID 17599775.
- ^ Schilders G, van Dijk E, Pruijn GJ (May 2007). "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing". Nucleic Acids Res 35 (8): 2564–72. doi:10.1093/nar/gkm082. PMC 1885644. PMID 17412707. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1885644.
- ^ a b Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". J Cell Sci 115 (Pt 1): 207–16. PMID 11801738.
- ^ Zamir I, Dawson J, Lavinsky RM, Glass CK, Rosenfeld MG, Lazar MA (Feb 1998). "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex". Proc Natl Acad Sci U S A 94 (26): 14400–5. doi:10.1073/pnas.94.26.14400. PMC 24996. PMID 9405624. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24996.
- ^ a b "Entrez Gene: C1D nuclear DNA-binding protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10438.
- ^ Yavuzer, U; Smith G C, Bliss T, Werner D, Jackson S P (Jul. 1998). "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D". Genes Dev. (UNITED STATES) 12 (14): 2188–99. doi:10.1101/gad.12.14.2188. ISSN 0890-9369. PMC 317006. PMID 9679063. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=317006.
Further reading
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Rothbarth K, Stammer H, Werner D (2002). "Proteasome-mediated degradation antagonizes critical levels of the apoptosis-inducing C1D protein". Cancer cell international 2 (1): 12. doi:10.1186/1475-2867-2-12. PMC 140130. PMID 12379155. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140130.
- Rothbarth K, Hunziker A, Stammer H, Werner D (2001). "Promoter of the gene encoding the 16 kDa DNA-binding and apoptosis-inducing C1D protein". Biochim. Biophys. Acta 1518 (3): 271–5. PMID 11311939.
- Rothbarth K, Spiess E, Juodka B et al. (1999). "Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D". J. Cell. Sci. 112 ( Pt 13): 2223–32. PMID 10362552.
- Haataja L, Groffen J, Heisterkamp N (1999). "Identification of a novel Rac3-interacting protein C1D". Int. J. Mol. Med. 1 (4): 665–70. PMID 9852280.
- Yavuzer U, Smith GC, Bliss T et al. (1998). "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D". Genes Dev. 12 (14): 2188–99. doi:10.1101/gad.12.14.2188. PMC 317006. PMID 9679063. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=317006.