C19orf2
Unconventional prefoldin RPB5 interactor is a protein that in humans is encoded by the C19orf2 gene.[1][2][3]
The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[3]
Interactions
C19orf2 has been shown to interact with DMAP1[4] and STAP1.[5]
References
- ^ Van Leuven F, Torrekens S, Moechars D, Hilliker C, Buellens M, Bollen M, Delabie J (Feb 1999). "Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease". Genomics 54 (3): 511–20. doi:10.1006/geno.1998.5609. PMID 9878255.
- ^ Dorjsuren D, Lin Y, Wei W, Yamashita T, Nomura T, Hayashi N, Murakami S (Dec 1998). "RMP, a Novel RNA Polymerase II Subunit 5-Interacting Protein, Counteracts Transactivation by Hepatitis B Virus X Protein". Mol Cell Biol 18 (12): 7546–55. PMC 109335. PMID 9819440. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109335.
- ^ a b "Entrez Gene: C19orf2 chromosome 19 open reading frame 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8725.
- ^ Delgermaa, Luvsanjav; Hayashi Naoyuki, Dorjsuren Dorjbal, Nomura Takahiro, Thuy Le Thi-Thu, Murakami Seishi (Oct. 2004). "Subcellular Localization of RPB5-Mediating Protein and Its Putative Functional Partner". Mol. Cell. Biol. (United States) 24 (19): 8556–66. doi:10.1128/MCB.24.19.8556-8566.2004. ISSN 0270-7306. PMC 516735. PMID 15367675. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=516735.
- ^ Gstaiger, Matthias; Luke Brian, Hess Daniel, Oakeley Edward J, Wirbelauer Christiane, Blondel Marc, Vigneron Marc, Peter Matthias, Krek Wilhelm (Nov. 2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science (United States) 302 (5648): 1208–12. doi:10.1126/science.1088401. PMID 14615539.
Further reading
- Liu L, McKeehan WL (2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity". Genomics 79 (1): 124–36. doi:10.1006/geno.2001.6679. PMID 11827465.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Wei W, Gu JX, Zhu CQ et al. (2003). "Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP)". Cell Res. 13 (2): 111–20. doi:10.1038/sj.cr.7290155. PMID 12737519.
- Gstaiger M, Luke B, Hess D et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science 302 (5648): 1208–12. doi:10.1126/science.1088401. PMID 14615539.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Delgermaa L, Hayashi N, Dorjsuren D et al. (2004). "Subcellular Localization of RPB5-Mediating Protein and Its Putative Functional Partner". Mol. Cell. Biol. 24 (19): 8556–66. doi:10.1128/MCB.24.19.8556-8566.2004. PMC 516735. PMID 15367675. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=516735.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.