CFLAR

CASP8 and FADD-like apoptosis regulator

Rendering based on PDB 3H11.

Available structures
PDB	3H11, 3H13

Identifiers

Symbols

CFLAR; CASH; CASP8AP1; CLARP; Casper; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT; c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS

External IDs

OMIM: 603599 MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR Gene

Gene Ontology
Molecular function	• cysteine-type endopeptidase activity • protein binding
Cellular component	• cytoplasm • CD95 death-inducing signaling complex
Biological process	• proteolysis • anti-apoptosis • induction of apoptosis by extracellular signals • positive regulation of I-kappaB kinase/NF-kappaB cascade • negative regulation of caspase activity • interspecies interaction between organisms
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
201.98 – 202.03 Mb

Chr 1:
58.77 – 58.82 Mb

PubMed search

[1]

[2]

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.^[1]^[2] Also called FLICE-like inhibitory protein (FLIP).

References

^ Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.
^ Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP". Nature 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161.

CFLAR

References

Further reading