Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor. protein which in humans is encoded by the CCR6 gene.[1] CCR6 has also recently been designated CD196 (cluster of differentiation 196).
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This protein belongs to family A of G protein-coupled receptor superfamily. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.[2]
The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids (molecular weight 42,494 Da).[1]
CCR6 has been associated with Crohn's disease.[3]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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