Bronidox

Bronidox

IUPAC name 5-Bromo-5-nitro-1,3-dioxane
Other names 5-Bromo-5-nitro-m-dioxane
Identifiers
CAS number	30007-47-7^Y=
PubChem	1807
ChemSpider	1741^Y
UNII	U184I9QBNM^Y
EC number	250-001-7
Jmol-3D images	Image 1
SMILES O=[N+]([O-])C1(Br)COCOC1
InChI InChI=1S/C4H6BrNO4/c5-4(6(7)8)1-9-3-10-2-4/h1-3H2^Y Key: XVBRCOKDZVQYAY-UHFFFAOYSA-N^Y InChI=1/C4H6BrNO4/c5-4(6(7)8)1-9-3-10-2-4/h1-3H2 Key: XVBRCOKDZVQYAY-UHFFFAOYAG
Properties
Molecular formula	C₄H₆BrNO₄
Molar mass	212 g mol⁻¹
Appearance	White crystalline powder
Melting point	60 °C^[1] 58.5−62 °C^[2]
Solubility in water	insoluble
Hazards
R-phrases	R22 R38
S-phrases	S36
Main hazards	Toxic
LD₅₀	590 mg/kg (mouse, oral) 455 mg/kg (rat, oral) 31 mg/kg (rat, ipr.) 2500 µg (mouse, skin) 2500 µg (rat, skin)^[3]
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Bronidox, or 5-bromo-5-nitro-1,3-dioxane, is an antimicrobial chemical compound.

Bronidox causes inhibition of enzyme activity in bacteria.^[4]

Bronidox is corrosive to metals.^[5]

Uses

Stabilizer
Surfactant
It is used in immunology for preserving antibodies and antisera in 0.1 - 0.5% concentration. It is used as preservative to avoid use of sodium azide.
Bactericide. Very effective against yeast and fungi.
Used in cosmetics since the mid-1970s as preservative for shampoos, foam bath, etc. Maximum concentration is 0.1 %.
Some users do not recommend use in preparations destined for in vivo or tissue culture work^[6]

^ 5-BROMO-5-NITRO-1,3-DIOXANE, chemicalland21.com
^ Bronidox
^ FSASAX
^ Ghannoum M, Thomson M, Bowman W, Al-Khalil S (1986). "Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox)". Folia Microbiol. (Praha) 31 (1): 19–31. doi:10.1007/BF02928676. PMID 3082729.
^ Bronidox, cognis.com
^ Bronidox, totalreproduction.com