Brinase

Brinase

Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	B01AD06
Chemical data
Formula	?
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Brinase (or brinolase) is a fibrinolytic enzyme, and a thrombolytic drug.^[1]

It is derived from Aspergillus oryzae.^[2]

References

^ Frisch EP (July 1972). "Clinical experience with brinase". J. Clin. Pathol. 25 (7): 654–5. doi:10.1136/jcp.25.7.654. PMC 477472. PMID 5070274. http://jcp.bmj.com/cgi/pmidlookup?view=long&pmid=5070274.
^ Roschlau WH (July 1972). "Thrombolytic properties and side effects of brinase (fibrinolytic enzyme from Aspergillus oryzae) in the dog". J. Clin. Pathol. 25 (7): 635–6. doi:10.1136/jcp.25.7.635. PMC 477457. PMID 5070267. http://jcp.bmj.com/cgi/pmidlookup?view=long&pmid=5070267.

External links

MeSH Brinolase

Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors	Abciximab • Eptifibatide • Tirofiban

ADP receptor/P2Y₁₂ inhibitors	thienopyridines (Clopidogrel, Prasugrel, Ticlopidine) • nucleotide/nucleoside analogs (Cangrelor, Elinogrel, Ticagrelor)

Prostaglandin analogue (PGI2)	Beraprost • Prostacyclin • Iloprost • Treprostinil

COX inhibitors	Acetylsalicylic acid/Aspirin^# • Aloxiprin • Carbasalate calcium • Indobufen • Triflusal

Thromboxane inhibitors	thromboxane synthase inhibitors (Dipyridamole, Picotamide) • receptor antagonist (Terutroban^†)

Phosphodiesterase inhibitors	Cilostazol • Dipyridamole • Triflusal

Other	Cloricromen • Ditazole

Anticoagulants

Vitamin K antagonists
(inhibit II, VII, IX, X)

coumarins: Acenocoumarol • Coumatetralyl • Dicoumarol • Ethyl biscoumacetate • Phenprocoumon • Warfarin^#

1,3-Indandiones: Clorindione • Diphenadione • Phenindione

other: Tioclomarol

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	low-molecular-weight heparin (Bemiparin, Certoparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin) oligosaccharides (Fondaparinux, Idraparinux) heparinoid (Danaparoid, Sulodexide, Dermatan sulfate)

Direct Xa inhibitors	xabans (Apixaban, Betrixaban, Edoxaban, Otamixaban, Rivaroxaban)

Direct thrombin (II) inhibitors

bivalent: Hirudin (Bivalirudin, Lepirudin, Desirudin)

univalent: Argatroban • Dabigatran • Melagatran^‡ • Ximelagatran^‡

Other

REG1 • Defibrotide • Ramatroban • Antithrombin III • Protein C (Drotrecogin alfa)

Thrombolytic drugs/
fibrinolytics

plasminogen activators: r-tPA (Alteplase, Reteplase, Tenecteplase) • UPA (Urokinase, Saruplase) • Streptokinase^# • Anistreplase • Monteplase

other serine endopeptidases: Ancrod • Fibrinolysin

Brinase

Non-medicinal

Citrate • EDTA • Oxalate

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase (Alanine, Arginyl, Aspartyl, Cystinyl, Leucyl, Glutamyl, Methionyl (1, 2), O)

3.4.13	Dipeptidase (1, 2, 3)

3.4.14	Dipeptidyl peptidase (Cathepsin C, Dipeptidyl peptidase-4) · Tripeptidyl peptidase (Tripeptidyl peptidase I, Tripeptidyl peptidase II)

3.4.15	Angiotensin-converting enzyme

3.4.16	Serine type carboxypeptidases: Cathepsin A · DD-transpeptidase

3.4.17	Metallocarboxypeptidases: Carboxypeptidase (A, A2, B, C, E, Glutamate II)

Other/ungrouped	Metalloexopeptidase

3.4.21-24: Endopeptidase

Serine proteases · Cysteine protease · Aspartic acid protease · Metalloendopeptidases

Other/ungrouped: Amyloid precursor protein secretase (Alpha secretase, Beta-secretase 1, Beta-secretase 2, Gamma secretase)

3.4.99: Unknown

Staphylokinase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Brinase

See also

References

External links