Blaise ketone synthesis

The Blaise ketone synthesis is the chemical reaction of acid chlorides with organozinc compounds to give ketones.[1] [2]

The reaction also works with organocuprates.[3][4]

Reviews have been written.[5] [6]

Contents

Variations

Blaise-Maire reaction

The Blaise-Maire reaction is the Blaise ketone synthesis using β-hydroxy acid chlorides to give β-hydroxyketones, which are converted into α,β-unsaturated ketones using sulfuric acid.[7]

References

  1. ^ Blaise, E. E.; Koehler, A. Bull. Soc. Chim. 1910, 7, 215.
  2. ^ Blaise, E. E. Bull. Soc. Chim. 1911, 9, 1.
  3. ^ Posner, G. H.; Whitten, C. E. Organic Syntheses, Coll. Vol. 6, p.248 (1988); Vol. 55, p.122 (1976). (Article)
  4. ^ Fujisawa, T.; Sato, T. Organic Syntheses, Coll. Vol. 8, p.441 (1993); Vol. 66, p.116 (1988). (Article)
  5. ^ Cason, J. Chem. Rev. 1947, 40, 17. (Review)
  6. ^ Shirley, D. A. Org. React. 1954, 8, 29. (Review)
  7. ^ Blaise, E. E.; Maire, M. Compt. Rend. 1907, 145, 73.

See also