Bis-tris methane

Bis-tris methane
IUPAC name

2-[Bis-(2-hydroxyethyl)-amino]-
2-hydroxymethyl-propane-1,3-diol
Other names

Bis-tris

Bis-(2-hydroxy-ethyl)-
amino-tris(hydroxymethyl)-methane

2,2-Bis(hydroxymethyl)-
2,2,2-nitrilotriethanol
Identifiers
CAS number 6976-37-0
RTECS number TY2900000
Jmol-3D images Image 1
Properties
Molecular formula C8H19NO5
Molar mass 209.2418 g/mol
Appearance white crystalline powder
Density  ? g/l, solid (25°C)
Melting point

102-106°C (375-379K)
Boiling point

(?K)
Solubility in water 67? g/100 ml (20°C)
Acidity (pKa) 6.46 @25°C
Hazards
MSDS External MSDS
R-phrases R36, R37, R38.
S-phrases S26, S36.
Main hazards Irritant.
NFPA 704
0
2
0
Flash point Non-flammable.
 Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Bis-tris is an abbreviation of the trivial name (Bis(2-hydroxyethyl)-amino-tris(hydroxymethyl)-methane) for 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol. It is generally used as a buffering agent in biochemistry. Bis-tris is an organic tertiary amine with labile protons having a pKa of 6.46 at 25°C. It is an effective buffer between the pH 5.8 and 7.3.

See also