| Content | |
|---|---|
| Description | interaction data. |
| Contact | |
| Research center | University of Edinburgh |
| Laboratory | Wellcome Trust Centre for Cell Biology and School of Biological Sciences, |
| Authors | Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Andrew Chatr-Aryamontri, Kara Dolinski, Michael Livstone, Julie Nixon, Rose Oughtred, Jennifer Rust, Andrew Winter, Mike Tyers, Nadine Kolas |
| Primary Citation | Stark & al. (2006)[1] |
| Access | |
| Website | http://thebiogrid.org |
| Tools | |
| Miscellaneous | |
| Version | 3.1.81 |
The Biological General Repository for Interaction Datasets (BioGRID) is a curated biological database of protein-protein and genetic interactions created in 2003 (originally referred to as simply the General Repository for Interaction Datasets (GRID) by Mike Tyers, Bobby-Joe Breitkreutz, and Chris Stark at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital. It strives to provide a comprehensive resource of protein–protein and genetic interactions for all major model organism species while attempting to remove redundancy to create a single mapping of interactions. Users of The BioGRID can search for their protein of interest and retrieve annotation, as well as physical and genetic interaction data as reported, by the primary literature and compiled by in house large-scale curation efforts. The BioGRID is hosted in Toronto, Ontario, Canada and is partnered with the Saccharomyces Genome Database. The BioGRID is funded by the BBSRC, NIH, and CIHR. BioGRID is a member of the International Molecular Exchange Consortium (IMEx).
Contents |
The BioGRID was originally published and released as simply the General Repository for Interaction Datasets but was later renamed to the BioGRID in order to more concisely describe the project, and help distinguish it from several unrelated projects with a similar name. Originally separated into organism specific databases, the newest version now provides a unified front end allowing for searches across several organisms simultaneously.
The Biological General Repository for Interaction Datasets (BioGRID) database (http://www.thebiogrid.org) was developed to house and distribute collections of protein and genetic interactions from major model organism species. BioGRID currently contains over 335,000 interactions from 17 different species, as derived from both high-throughput studies and conventional focused studies. Through comprehensive curation efforts, BioGRID now includes a virtually complete set of interactions reported to date in the primary literature for budding yeast Saccharomyces cerevisiae, thale cress Arabidopsis thaliana and the fission yeast Schizosaccharomyces pombe. A number of new features have been added to the BioGRID including an improved user interface to display interactions based on different attributes, a mirror site and a dedicated interaction management system to coordinate curation across different locations. The BioGRID provides interaction data with monthly updates to Saccharomyces Genome Database, Flybase, GeneDB, TAIR and Entrez Gene. Source code for the BioGRID and the linked Osprey Network Visualization System is now freely available without restriction.
The following organisms are currently supported within the BioGRID, but not all may contain interactions in the most recent build: