Beta-thromboglobulin (β-thromboglobulin, also called Pro-Platelet basic protein) is a protein that is stored in alpha-granules of platelets and released in large amounts after platelet activation.[1]
It is a type of Chemokine (C-X-C motif) ligand 7.[2]
It is a chemoattractant, strongly for fibroblasts and weakly for neutrophils. It is a stimulator of mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator synthesis in human fibroblasts.[1]
Beta-Thromboglobulin also affects megakaryocyte maturation, and thus helps in regulating platelet production.[1]
Levels of Beta-Thromboglobulin is used to index platelet activation. It is measured by ELISA in blood plasma or urine, and often in conjunction with Platelet factor 4)[1]
It is elevated in diabetes mellitus.[3]