Benzhydryl compounds

Benzhydryl compounds are compounds that are "diphenylmethane" containing, i.e. two benzene rings adjoined by a single carbon. This simple definition does not include heteroaromatic ring moieties, which would grossify the situation even further. Although it may still be desired to include these for the purposes of 'completeness' they ought to be kept separate to avoid confusion.

1 Carboaromatic
2 Hetereoaromatic
3 References
4 External links

Carboaromatic

Alcohols

Acyclic: pridinol
Pyrolidino: diphenylprolinol
2-Piperidine: pipradrol
4-Piperidine: terfenadine, fexofenadine
Benzilic ester: QNB, JB-336, JB-318, benactyzine

Alkenes

Tricycle: amitriptyline, melitracen, cyclobenzaprine, tianeptine, amineptine, clopenthixol chlorprothixene flupentixol thiothixene zuclopenthixol
Tricyclic and piperidine: pimethixene, cyproheptadine
Acyclic: gilutensin

Alkyl(amine)s

Acyclic: (3-phenylpropylamine), tolpropamine, tolterodine
Piperidine: desoxypipradrol, budipine^[1]
N-alkyl-4-piperidinol: penfluridol
N-arylalkyl-piperidine: pimozide
Tetrahydronaphthalene: tametraline (4-phenylaminotetralin), sertraline
Tetrahydroisoquinoline: nomifensine, diclofensine "tetrahydronaphisoquinoline", dinapsoline (c.f. doxanthrine and dinoxyline)
Pyrroloisoquinoline: JNJ-7925476
Indanamine: Lu 19-005
Tricyclic: 9-Aminomethyl-9,10-dihydroanthracene, phenindamine (see MPTP)
Tetracyclic: maprotiline, dihydrexidine, butaclamol, ecopipam
Tetrahydrobenzazepine: SKF-83959, SKF-82958, SKF-81297, SKF 38393, fenoldopam, 6-Br-APB, SCH 23390
Piperazine: amperozide
Triazaspiro: fluspirilene

Hetereoaromatic

Heteroaromatic rings

Alkene: thiambutene, loratidine
Alkylamine: A-86929, amfonelic acid

Benzenes linked by a non-carbon atom

Nitrogen: promethazine, imipramine, acepromazine, chlorpromazine, fluphenazine, mesoridazine, levomepromazine, perazine, periciazine, perphenazine, prochlorperazine, sulforidazine, thioridazine, trifluoperazine, triflupromazine, clozapine, thiethylperazine
Indolic nitrogen: sertindole
Oxygen: loxapine, asenapine, tyrima

Benzene and heterocycle linked through a non-carbon

Olanzapine

References

^ U.S. Patent 4,022,786

External links

Psychostimulants, agents used for ADHD, and nootropics (N06B)

Centrally acting sympathomimetics

Amphetamine • Amphetaminil • Atomoxetine • Dexmethylphenidate • Dextroamphetamine • Dextromethamphetamine • Fencamfamine • Fenethylline • Lisdexamfetamine • Methylphenidate • Mesocarb • Pemoline • Pipradrol • Prolintane

Xanthine derivatives

Caffeine • Fenethylline

Glutamate receptor

Racetams	Aniracetam • Nefiracetam • Noopept • Oxiracetam • Phenylpiracetam • Piracetam • Pramiracetam

Ampakines	CX-516 • CX-546 • CX-614 • CX-691 • CX-717 • IDRA-21 • LY-404,187 • LY-503,430 • PEPA • S-18986 • Sunifiram • Unifiram

Eugeroics / Benzhydryl compounds

Adrafinil • Armodafinil • Modafinil

Histamine H3 receptor antagonists

A-349,821 • ABT-239 • Ciproxifan • GSK-189,254

GABA_A α₅ inverse agonists

α₅IA • L-655,708 • PWZ-029 • Suritozole • TB-21007 • ZK-93426

Dopamine D1 receptor agonists

A-77636 • Dihydrexidine • Dinapsoline • Doxanthrine • SKF-81297 • 6-Br-APB

α7 nicotinic agonists / PAMs

AR-R17779 • PNU-282,987 • SSR-180,711

Prolyl endopeptidase inhibitors

S-17092

Alpha-adrenergic agonists

Clonidine • Guanfacine

Plants

Paullinia cupana (Guarana) • Eleutherococcus senticosus

Antioxidants

Stabilized R-(+)-lipoic acid (RLA)

Other psychostimulants and nootropics

Acetylcarnitine • Adafenoxate • Bifemelane • Carbenoxolone • Citicoline • Cyprodenate • Ensaculin • Idebenone • Ispronicline • Deanol • Dimebon • Fipexide • Leteprinim • Linopirdine • Meclofenoxate • Nizofenone • P7C3 • Pirisudanol • Pyritinol • Rubidium • Sulbutiamine • Taltirelin • Tricyanoaminopropene • Vinpocetine • Phosphatidylserine • Tyrosine

M: PSO/PSI

mepr

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc(eval/thrp), drug(N5A/5B/5C/6A/6B/6D)

Antihistamines (R06)

Aminoalkyl ethers	Bromazine/Bromodiphenhydramine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine

Substituted alkylamines	Brompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine

Substituted ethylenediamines	Chloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)

Phenothiazine derivatives	Alimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine

Piperazine derivatives	Buclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide

Others for systemic use	Antazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)

For topical use	Bamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine

Antiallergic agents excluding corticosteroids	Antazoline • Azelastine

Other antiallergics	Emedastine • Epinastine • Ketotifen • Montelukast • Olopatadine

Deliriants (anticholinergic hallucinogens)

Tropanes	Atropine • CAR-226,086 • Hyoscyamine • Scopolamine

Benzilates	Benactyzine • CAR-301,060 • CAR-302,196 • CAR-302,282 • CAR-302,368 • CAR-302,537 • CAR-302,668 • CS-27349 • Ditran • EA-3167 • EA-3443 • EA-3580 • EA-3834 • N-Ethyl-3-piperidyl benzilate • N-Methyl-3-piperidyl benzilate • 3-Quinuclidinyl benzilate • WIN-2299

Antihistamines	Benzhydryl compounds (Cyclizine • Dimenhydrinate • Diphenhydramine), Doxylamine • Promethazine

Others	Benzydamine • Dicyclomine • Biperiden • Trihexyphenidyl