BCL2L2

BCL2-like 2

PDB rendering based on 1mk3.
Identifiers
Symbols BCL2L2; BCL-W; BCL2-L-2; BCLW; KIAA0271
External IDs OMIM: 601931 MGI: 108052 HomoloGene: 2989 GeneCards: BCL2L2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 599 12050
Ensembl ENSG00000129473 ENSMUSG00000089682
UniProt Q92843 P70345
RefSeq (mRNA) NM_001199839.1 NM_007537.1
RefSeq (protein) NP_001186768.1 NP_031563.1
Location (UCSC) Chr 14:
23.78 – 23.78 Mb		 Chr 14:
55.5 – 55.51 Mb
PubMed search [1] [2]

Bcl-2-like protein 2 is a protein that in humans is encoded by the BCL2L2 gene.[1][2]

This gene encodes a pro-survival (anti-apoptotic) member of the bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.[2]

Relative to its Bcl-2 counterparts there is considerably less data on this particular protein however much effort is being made to further understand its cellular roles. Located on chromosome 14q11 it appears to be redundant in most tissues apart from specific examples. It was originally discovered by Leonie Gibson, Suzanne Cory and colleagues at the Walter and Eliza Hall Institute of Medical Research, who called it Bcl-w..[3]

Interactions

BCL2L2 has been shown to interact with PPP1CA,[4] BCL2L11[5][6] and Bcl-2-associated death promoter.[7][4][8][9]

References

  1. ^ Gibson L, Holmgreen SP, Huang DC, Bernard O, Copeland NG, Jenkins NA, Sutherland GR, Baker E, Adams JM, Cory S (Oct 1996). "bcl-w, a novel member of the bcl-2 family, promotes cell survival". Oncogene 13 (4): 665–75. PMID 8761287. 
  2. ^ a b "Entrez Gene: BCL2L2 BCL2-like 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=599. 
  3. ^ Gibson L, Holmgreen SP, Huang DC, et al. (1996). "bcl-w, a novel member of the bcl-2 family, promotes cell survival.". Oncogene 13 (4): 665–75. PMID 8761287. 
  4. ^ a b Ayllón, Verónica; Cayla Xavier, García Alphonse, Fleischer Aarne, Rebollo Angelita (Jul. 2002). "The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad". Eur. J. Immunol. (Germany) 32 (7): 1847–55. doi:10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7. ISSN 0014-2980. PMID 12115603. 
  5. ^ Hsu, S Y; Lin P, Hsueh A J (Sep. 1998). "BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members". Mol. Endocrinol. (UNITED STATES) 12 (9): 1432–40. doi:10.1210/me.12.9.1432. ISSN 0888-8809. PMID 9731710. 
  6. ^ O'Connor, L; Strasser A, O'Reilly L A, Hausmann G, Adams J M, Cory S, Huang D C (Jan. 1998). "Bim: a novel member of the Bcl-2 family that promotes apoptosis". EMBO J. (ENGLAND) 17 (2): 384–95. doi:10.1093/emboj/17.2.384. ISSN 0261-4189. PMC 1170389. PMID 9430630. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170389. 
  7. ^ Chen, Lin; Willis Simon N, Wei Andrew, Smith Brian J, Fletcher Jamie I, Hinds Mark G, Colman Peter M, Day Catherine L, Adams Jerry M, Huang David C S (Feb. 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell (United States) 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. ISSN 1097-2765. PMID 15694340. 
  8. ^ Bae, J; Hsu S Y, Leo C P, Zell K, Hsueh A J (Oct. 2001). "Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis". Apoptosis (United States) 6 (5): 319–30. doi:10.1023/A:1011319901057. ISSN 1360-8185. PMID 11483855. 
  9. ^ Holmgreen, S P; Huang D C, Adams J M, Cory S (Jun. 1999). "Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members". Cell Death Differ. (ENGLAND) 6 (6): 525–32. doi:10.1038/sj.cdd.4400519. ISSN 1350-9047. PMID 10381646. 

Further reading