Barakol

Barakol
Systematic (IUPAC) name
2,5-Dimethyl-3aH-pyrano[2,3,4-de]-1-benzopyran-3a,8-diol
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 24506-68-1 Y
ATC code None
PubChem CID 3080731
ChemSpider 2338470 Y
Chemical data
Formula C13H12O4 
Mol. mass 232.231 g/mol
SMILES eMolecules & PubChem
 Y(what is this?)  (verify)

Barakol is a compound found in the plant Senna siamea,[1] which is used in traditional herbal medicine. It has sedative and anxiolytic effects,[2][3] but use for these purposes is now discouraged due to hepatotoxicity.[4]

References

  1. ^ Padumanonda T, Gritsanapan W (March 2006). "Barakol contents in fresh and cooked Senna siamea leaves". The Southeast Asian Journal of Tropical Medicine and Public Health 37 (2): 388–93. PMID 17125004. 
  2. ^ Thongsaard W, Pongsakorn S, Sudsuang R, Bennett GW, Kendall DA, Marsden CA (January 1997). "Barakol, a natural anxiolytic, inhibits striatal dopamine release but off uptake in vitro". European Journal of Pharmacology 319 (2-3): 157–64. doi:10.1016/S0014-2999(96)00850-3. PMID 9042586. 
  3. ^ Sukma M, Chaichantipyuth C, Murakami Y, Tohda M, Matsumoto K, Watanabe H (November 2002). "CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk". Journal of Ethnopharmacology 83 (1-2): 87–94. doi:10.1016/S0378-8741(02)00206-4. PMID 12413711. 
  4. ^ Hongsirinirachorn M, Threeprasertsuk S, Chutaputti A (June 2003). "Acute hepatitis associated with Barakol". Journal of the Medical Association of Thailand = Chotmaihet Thangphaet 86 Suppl 2: S484–9. PMID 12930029.