Bannered routes of U.S. Route 322

A total of at least three bannered routes of U.S. Route 322 currently exist.

State College business route

U.S. Route 322 Business is a 9-mile route following the original alignment of its partent. After the mainline of the route was shifted on to the Mount Nittany Expressway (whose western portion is now also part of Interstate 99), the business designation came into place. The entire route is known as Atherton Street, which begins in the west as a four-laner that is mostly bordered by residential development. After passing by the southern entrance to Penn State University, the highway narrows to two lanes through the city center. West of downtown, the route is four lanes and offers a mix of periodic commercial development and more rural scenes.

Downingtown truck route

U.S. Route 322 Truck is a 4-mile route bypass of Downingtown, Pennsylvania that provides a route for trucks around a low clearance underpass. The route travels east from the mainline along U.S. Route 30 Business (Lancaster Avenue), which is lined with shopping centers. It then turns south onto Quarry Road near an interchange with U.S. Route 30, and travels west past industrial development on Boot Road.

West Chester business route

U.S. Route 322 Business is a 4-mile route following the original alignment of its parent. In 1964, the West Chester Bypass was completed around this Philadelphia suburb and the prior tract of US 322 became a business loop. After travelling through heavily subruban-style areas at its western end, it becomes a narrow city street, including using Market Street and Gay Street as a one-way couplet through downtown. The route then shifts abruptly south and passes West Chester University, before meeting up with the southern edge of the 322 freeway.