Baicalin

Baicalin
Identifiers
CAS number 21967-41-9 N
PubChem 64982
ChemSpider 58507 Y
UNII 347Q89U4M5 Y
ChEBI CHEBI:2981 Y
ChEMBL CHEMBL485818 Y
Jmol-3D images Image 1
Properties
Molecular formula C21H18O11
Molar mass 446.36 g mol−1
Exact mass 446.084911 g mol−1
Melting point

202-205 °C, 475-478 K, 396-401 °F

 N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Baicalin is a flavone, a type of flavonoid. It is found in several species in the genus Scutellaria, including Scutellaria lateriflora (blue skullcap). There are 10 mg/g baicalin in Scutellaria galericulata (common skullcap) leaves.[1] It is a component of Chinese medicinal herb Huang-chin (Scutellaria baicalensis).

It is one of the active ingredients of Sho-Saiko-To, an herbal supplement believed to enhance liver health.

Baicalin is the glucuronide of baicalein.

Baicalin is a known prolyl endopeptidase inhibitor[2] and affects the GABA receptors.

References

  1. ^ P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
  2. ^ Tarragó T, Kichik N, Claasen B, Prades R, Teixidó M, Giralt E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorganic and Medicinal Chemistry. 2008 Aug 1;16(15):7516-24. PMID 18650094

External links