BTG3

BTG family, member 3

Identifiers

BTG3; ANA; MGC8928; TOB5; TOB55; TOFA

External IDs

OMIM: 605674 MGI: 109532 HomoloGene: 4953 GeneCards: BTG3 Gene

Gene Ontology
Cellular component	• cytoplasm
Biological process	• negative regulation of cell proliferation • negative regulation of mitotic cell cycle
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 21:
18.97 – 18.99 Mb

n/a

PubMed search

[1]

[2]

Protein BTG3 is a protein that in humans is encoded by the BTG3 gene.^[1]^[2]

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system.^[2]

References

^ Yoshida Y, Matsuda S, Ikematsu N, Kawamura-Tsuzuku J, Inazawa J, Umemori H, Yamamoto T (Jun 1998). "ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system". Oncogene 16 (20): 2687–93. doi:10.1038/sj.onc.1201805. PMID 9632145.
^ ^a ^b "Entrez Gene: BTG3 BTG family, member 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10950.

Matsuda S, Rouault J, Magaud J, Berthet C (2001). "In search of a function for the TIS21/PC3/BTG1/TOB family". FEBS Lett. 497 (2–3): 67–72. doi:10.1016/S0014-5793(01)02436-X. PMID 11377414.
Guéhenneux F, Duret L, Callanan MB et al. (1997). "Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle". Leukemia 11 (3): 370–5. doi:10.1038/sj.leu.2400599. PMID 9067576.
Hattori M, Fujiyama A, Taylor TD et al. (2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Birot A, Duret L, Bartholin L et al. (2000). "Identification and molecular analysis of BANP". Gene 253 (2): 189–96. doi:10.1016/S0378-1119(00)00244-4. PMID 10940556.
Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMID 11429045.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Ou YH, Chung PH, Hsu FF et al. (2007). "The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1". EMBO J. 26 (17): 3968–80. doi:10.1038/sj.emboj.7601825. PMC 1994125. PMID 17690688. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1994125.

BTG3

References

Further reading