BTG1

B-cell translocation gene 1, anti-proliferative
Identifiers
Symbols BTG1;
External IDs OMIM109580 MGI88215 HomoloGene37521 GeneCards: BTG1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 694 12226
Ensembl ENSG00000133639 ENSMUSG00000036478
UniProt P62324 n/a
RefSeq (mRNA) NM_001731 NM_007569.2
RefSeq (protein) NP_001722 NP_031595.1
Location (UCSC) Chr 12:
92.53 – 92.54 Mb
Chr 10:
96.08 – 96.09 Mb
PubMed search [1] [2]

Protein BTG1 is a protein that in humans is encoded by the BTG1 gene.[1][2]

The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. It negatively regulates cell proliferation.[2]

Interactions

BTG1 has been shown to interact with CNOT7,[3][4] HOXB9,[5] PRMT1[6][7] and CNOT8.[8][4]

References

  1. ^ Iwai K, Hirata K, Ishida T, Takeuchi S, Hirase T, Rikitake Y, Kojima Y, Inoue N, Kawashima S, Yokoyama M (Mar 2004). "An anti-proliferative gene BTG1 regulates angiogenesis in vitro". Biochem Biophys Res Commun 316 (3): 628–35. doi:10.1016/j.bbrc.2004.02.095. PMID 15033446. 
  2. ^ a b "Entrez Gene: BTG1 B-cell translocation gene 1, anti-proliferative". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=694. 
  3. ^ Bogdan, J A; Adams-Burton C, Pedicord D L, Sukovich D A, Benfield P A, Corjay M H, Stoltenborg J K, Dicker I B (Dec. 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J.. 336 (ENGLAND) ( Pt 2): 471–81. ISSN 0264-6021. PMC 1219893. PMID 9820826. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1219893. 
  4. ^ a b Prévôt, D; Morel A P, Voeltzel T, Rostan M C, Rimokh R, Magaud J P, Corbo L (Mar. 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. (United States) 276 (13): 9640–8. doi:10.1074/jbc.M008201200. ISSN 0021-9258. PMID 11136725. 
  5. ^ Prévôt, D; Voeltzel T, Birot A M, Morel A P, Rostan M C, Magaud J P, Corbo L (Jan. 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. (UNITED STATES) 275 (1): 147–53. doi:10.1074/jbc.275.1.147. ISSN 0021-9258. PMID 10617598. 
  6. ^ Lin, W J; Gary J D, Yang M C, Clarke S, Herschman H R (Jun. 1996). "The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase". J. Biol. Chem. (UNITED STATES) 271 (25): 15034–44. doi:10.1074/jbc.271.25.15034. ISSN 0021-9258. PMID 8663146. 
  7. ^ Berthet, Cyril; Guéhenneux Fabienne, Revol Valérie, Samarut Christiane, Lukaszewicz Agnès, Dehay Colette, Dumontet Charles, Magaud Jean-Pierre, Rouault Jean-Pierre (Jan. 2002). "Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects". Genes Cells (England) 7 (1): 29–39. doi:10.1046/j.1356-9597.2001.00497.x. ISSN 1356-9597. PMID 11856371. 
  8. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading