BRD8

Bromodomain containing 8

Identifiers

BRD8; SMAP; SMAP2; p120

External IDs

OMIM: 602848 MGI: 1925906 HomoloGene: 41790 GeneCards: BRD8 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • thyroid hormone receptor activity
Cellular component	• nucleus • nucleus • nucleolus • mitochondrion • NuA4 histone acetyltransferase complex
Biological process	• transcription, DNA-dependent • regulation of transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • signal transduction • cell surface receptor linked signaling pathway • chromatin modification • regulation of growth • histone H4 acetylation • histone H2A acetylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
137.48 – 137.51 Mb

Chr 18:
34.76 – 34.78 Mb

PubMed search

[1]

[2]

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.^[1]^[2]^[3]

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.^[3]

Interactions

BRD8 has been shown to interact with Thyroid hormone receptor beta^[2] and Retinoid X receptor alpha.^[4]

References

^ Nielsen MS, Petersen CM, Gliemann J, Madsen P (Jun 1996). "Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain". Biochim Biophys Acta 1306 (1): 14–6. PMID 8611617.
^ ^a ^b Monden T, Wondisford FE, Hollenberg AN (Dec 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". J Biol Chem 272 (47): 29834–41. doi:10.1074/jbc.272.47.29834. PMID 9368056.
^ ^a ^b "Entrez Gene: BRD8 bromodomain containing 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10902.
^ Monden, T; Kishi M, Hosoya T, Satoh T, Wondisford F E, Hollenberg A N, Yamada M, Mori M (Oct. 1999). "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers". Mol. Endocrinol. (UNITED STATES) 13 (10): 1695–703. doi:10.1210/me.13.10.1695. ISSN 0888-8809. PMID 10517671.

Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Monden T, Kishi M, Hosoya T, et al. (1999). "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers". Mol. Endocrinol. 13 (10): 1695–703. doi:10.1210/me.13.10.1695. PMID 10517671.
Lai F, Godley LA, Joslin J, et al. (2001). "Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)". Genomics 71 (2): 235–45. doi:10.1006/geno.2000.6414. PMID 11161817.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=350560.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Benevolenskaya EV, Murray HL, Branton P, et al. (2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation". Mol. Cell 18 (6): 623–35. doi:10.1016/j.molcel.2005.05.012. PMID 15949438.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Natsume W, Tanabe K, Kon S, et al. (2006). "SMAP2, a Novel ARF GTPase-activating Protein, Interacts with Clathrin and Clathrin Assembly Protein and Functions on the AP-1–positive Early Endosome/Trans-Golgi Network". Mol. Biol. Cell 17 (6): 2592–603. doi:10.1091/mbc.E05-10-0909. PMC 1475504. PMID 16571680. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1475504.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

BRD8

Interactions

References

Further reading