BMP2K
BMP-2-inducible protein kinase is an enzyme that in humans is encoded by the BMP2K gene.[1]
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.[1]
References
Further reading
- Hoffmann A, Gross G (2002). "BMP signaling pathways in cartilage and bone formation". Crit. Rev. Eukaryot. Gene Expr. 11 (1–3): 23–45. PMID 11693963.
- Ueki N, Oda T, Kondo M et al. (1999). "Selection system for genes encoding nuclear-targeted proteins". Nat. Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615.
- Kearns AE, Donohue MM, Sanyal B, Demay MB (2001). "Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro". J. Biol. Chem. 276 (45): 42213–8. doi:10.1074/jbc.M106163200. PMID 11500515.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gevaert K, Goethals M, Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Arikawa T, Omura K, Morita I (2004). "Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells". J. Cell. Physiol. 200 (3): 400–6. doi:10.1002/jcp.20031. PMID 15254968.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Medici M, van Meurs JB, Rivadeneira F et al. (2006). "BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study". J. Bone Miner. Res. 21 (6): 845–54. doi:10.1359/jbmr.060306. PMID 16753015.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.