BBSome
The BBSome is a component of the basal body and is involved in formation of the primary cilium.[1][2] The BBSome is a complex of seven Bardet–Biedl syndrome (BBS) proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9. In addition the BBSome contains the BBIP10 protein.[3] The BBSome was first identified in 2007 by Peter K. Jackson and colleagues.[4]
Assembly
BBSome assembly has been shown to be mediated by a complex containing a further three BBS proteins: BBS6, BBS10 and BBS12. In addition chaperonins of the CCT/TRiC family are involved.[5]
References
- ^ Sheffield VC (2010). "The blind leading the obese: the molecular pathophysiology of a human obesity syndrome". Trans. Am. Clin. Climatol. Assoc. 121: 172–81; discussion 181–2. PMC 2917141. PMID 20697559. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2917141.
- ^ Jin H, White SR, Shida T, et al. (June 2010). "The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia". Cell 141 (7): 1208–19. doi:10.1016/j.cell.2010.05.015. PMID 20603001. http://linkinghub.elsevier.com/retrieve/pii/S0092-8674(10)00551-9.
- ^ Jin H, Nachury MV (June 2009). "The BBSome". Curr. Biol. 19 (12): R472–3. doi:10.1016/j.cub.2009.04.015. PMID 19549489.
- ^ Nachury MV, Loktev AV, Zhang Q, et al. (June 2007). "A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis". Cell 129 (6): 1201–13. doi:10.1016/j.cell.2007.03.053. PMID 17574030.
- ^ Seo S, Baye LM, Schulz NP, et al. (January 2010). "BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly". Proc. Natl. Acad. Sci. U.S.A. 107 (4): 1488–93. doi:10.1073/pnas.0910268107. PMC 2824390. PMID 20080638. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2824390.