Brain-specific angiogenesis inhibitor 1

Identifiers

BAI1; FLJ41988; GDAIF

External IDs

OMIM: 602682 MGI: 1933736 HomoloGene: 1287 IUPHAR: BAI1 GeneCards: BAI1 Gene

Gene Ontology
Molecular function	• G-protein coupled receptor activity • protein binding
Cellular component	• plasma membrane • integral to plasma membrane • cell-cell junction • integral to membrane
Biological process	• cell adhesion • signal transduction • G-protein coupled receptor protein signaling pathway • neuropeptide signaling pathway • axonogenesis • peripheral nervous system development • negative regulation of cell proliferation • negative regulation of angiogenesis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
143.53 – 143.63 Mb

Chr 15:
74.35 – 74.42 Mb

PubMed search

[1]

[2]

Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene.^[1]^[2] Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas^[2]

Interactions

Brain-specific angiogenesis inhibitor 1 has been shown to interact with BAIAP3^[3] and MAGI1.^[4]

References

^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023.
^ ^a ^b "Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=575.
^ Shiratsuchi, T; Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y (Oct. 1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochem. Biophys. Res. Commun. (UNITED STATES) 251 (1): 158–65. doi:10.1006/bbrc.1998.9408. ISSN 0006-291X. PMID 9790924.
^ Shiratsuchi, T; Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (Jun. 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochem. Biophys. Res. Commun. (UNITED STATES) 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. ISSN 0006-291X. PMID 9647739.

Van Meir EG, Polverini PJ, Chazin VR, et al. (1995). "Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells". Nat. Genet. 8 (2): 171–6. doi:10.1038/ng1094-171. PMID 7531056.
Nishimori H, Shiratsuchi T, Urano T, et al. (1997). "A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis". Oncogene 15 (18): 2145–50. doi:10.1038/sj.onc.1201542. PMID 9393972.
Shiratsuchi T, Futamura M, Oda K, et al. (1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochem. Biophys. Res. Commun. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739.
Fukushima Y, Oshika Y, Tsuchida T, et al. (1998). "Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer". Int. J. Oncol. 13 (5): 967–70. PMID 9772287.
Shiratsuchi T, Oda K, Nishimori H, et al. (1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochem. Biophys. Res. Commun. 251 (1): 158–65. doi:10.1006/bbrc.1998.9408. PMID 9790924.
Oda K, Shiratsuchi T, Nishimori H, et al. (1999). "Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1". Cytogenet. Cell Genet. 84 (1–2): 75–82. doi:10.1159/000015219. PMID 10343108.
Wu Y, Dowbenko D, Spencer S, et al. (2000). "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase". J. Biol. Chem. 275 (28): 21477–85. doi:10.1074/jbc.M909741199. PMID 10748157.
Koh JT, Lee ZH, Ahn KY, et al. (2001). "Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein". Brain Res. Mol. Brain Res. 87 (2): 223–37. doi:10.1016/S0169-328X(01)00004-3. PMID 11245925.
Duda DG, Sunamura M, Lozonschi L, et al. (2002). "Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis". Br. J. Cancer 86 (3): 490–6. doi:10.1038/sj.bjc.6600067. PMC 2375213. PMID 11875720. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2375213.
Lim IA, Hall DD, Hell JW (2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501.
Mori K, Kanemura Y, Fujikawa H, et al. (2002). "Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells". Neurosci. Res. 43 (1): 69–74. doi:10.1016/S0168-0102(02)00018-4. PMID 12074842.
Kaur B, Brat DJ, Calkins CC, Van Meir EG (2003). "Brain Angiogenesis Inhibitor 1 Is Differentially Expressed in Normal Brain and Glioblastoma Independently of p53 Expression". Am. J. Pathol. 162 (1): 19–27. doi:10.1016/S0002-9440(10)63794-7. PMC 1851137. PMID 12507886. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1851137.
Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell Proteomics 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Koh JT, Kook H, Kee HJ, et al. (2004). "Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin". Exp. Cell Res. 294 (1): 172–84. doi:10.1016/j.yexcr.2003.11.008. PMID 14980512.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A:
Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3

Purinergic	Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)

Serotonin	(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)

Other	Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane

Other	Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate · Lysophosphatidic acid (1, 2, 3, 4, 5, 6) · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)

Other	Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)

Other	Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)

Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)

Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)

Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

Brain-specific angiogenesis inhibitor 1

Interactions

References

Further reading