TNFRSF13C

Tumor necrosis factor receptor superfamily, member 13C

PDB rendering based on 1oqe.

Available structures
PDB	1MPV, 1OQE, 1OSX, 1P0T, 2HFG

Identifiers

Symbols

TNFRSF13C; BAFF-R; BAFFR; CD268; CVID4; MGC138235

External IDs

OMIM: 606269 MGI: 1919299 HomoloGene: 49897 GeneCards: TNFRSF13C Gene

Gene Ontology
Molecular function	• receptor activity
Cellular component	• external side of plasma membrane • membrane • integral to membrane
Biological process	• B cell homeostasis • positive regulation of germinal center formation • positive regulation of B cell proliferation • T cell costimulation • B cell costimulation • positive regulation of T cell proliferation • positive regulation of interferon-gamma biosynthetic process • regulation of immune response
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 22:
42.32 – 42.32 Mb

Chr 15:
82.05 – 82.05 Mb

PubMed search

[1]

[2]

Tumor necrosis factor receptor superfamily member 13C is a protein that in humans is encoded by the TNFRSF13C gene.^[1]^[2]

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular phenylalanine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.^[2]

References

^ Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C (Sep 2001). "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF". Science 293 (5537): 2108–11. doi:10.1126/science.1061965. PMID 11509692.
^ ^a ^b "Entrez Gene: TNFRSF13C tumor necrosis factor receptor superfamily, member 13C". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115650.

Laâbi Y, Egle A, Strasser A (2002). "TNF cytokine family: more BAFF-ling complexities.". Curr. Biol. 11 (24): R1013–6. doi:10.1016/S0960-9822(01)00613-3. PMID 11747837.
Defrance T, Casamayor-Pallejà M, Krammer PH (2003). "The life and death of a B cell.". Adv. Cancer Res. 86: 195–225. doi:10.1016/S0065-230X(02)86006-7. PMID 12374279.
Ambrose CM (2003). "BAFF-R.". J. Biol. Regul. Homeost. Agents 16 (3): 211–3. PMID 12456020.
Bossen C, Schneider P (2007). "BAFF, APRIL and their receptors: structure, function and signaling.". Semin. Immunol. 18 (5): 263–75. doi:10.1016/j.smim.2006.04.006. PMID 16914324.
Treml LS, Crowley JE, Cancro MP (2007). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.". Semin. Immunol. 18 (5): 297–304. doi:10.1016/j.smim.2006.07.001. PMID 16919470.
Kalled SL (2007). "Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production.". Semin. Immunol. 18 (5): 290–6. doi:10.1016/j.smim.2006.06.002. PMID 16931038.
Mackay F, Leung H (2007). "The role of the BAFF/APRIL system on T cell function.". Semin. Immunol. 18 (5): 284–9. doi:10.1016/j.smim.2006.04.005. PMID 16931039.
Schneider P, MacKay F, Steiner V, et al. (1999). "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.". J. Exp. Med. 189 (11): 1747–56. doi:10.1084/jem.189.11.1747. PMC 2193079. PMID 10359578. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193079.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Yan M, Brady JR, Chan B, et al. (2002). "Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency.". Curr. Biol. 11 (19): 1547–52. doi:10.1016/S0960-9822(01)00481-X. PMID 11591325.
Rolink AG, Melchers F (2002). "BAFFled B cells survive and thrive: roles of BAFF in B-cell development.". Curr. Opin. Immunol. 14 (2): 266–75. doi:10.1016/S0952-7915(02)00332-1. PMID 11869903.
Xu LG, Shu HB (2003). "TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production.". J. Immunol. 169 (12): 6883–9. PMID 12471121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Kim HM, Yu KS, Lee ME, et al. (2003). "Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation.". Nat. Struct. Biol. 10 (5): 342–8. doi:10.1038/nsb925. PMID 12715002.
Liu Y, Hong X, Kappler J, et al. (2003). "Ligand-receptor binding revealed by the TNF family member TALL-1.". Nature 423 (6935): 49–56. doi:10.1038/nature01543. PMID 12721620.
Gordon NC, Pan B, Hymowitz SG, et al. (2003). "BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.". Biochemistry 42 (20): 5977–83. doi:10.1021/bi034017g. PMID 12755599.

PDB gallery

1oqe: Crystal structure of sTALL-1 with BAFF-R

1osx: Solution Structure of the Extracellular Domain of BLyS Receptor 3 (BR3)

1p0t: Crystal Structure of the BAFF-BAFF-R complex (part II)

2hfg: Crystal structure of hBR3 bound to CB3s-Fab

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 (a-c, 1A, 1D, 1E) · CD2 · CD3 (γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 (a) · CD9 · CD10 · CD11 (a, b, c) · CD13 · CD14 · CD15 · CD16 (A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 (A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 (a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 (a, b, c, d, e, f) · CD50

51-100	CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 (E, L, P) · CD63 · CD64 (A, B, C) · CD66 (a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 (a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 (a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD96 · CD97 · CD98 · CD99 · CD100

101-150	CD101 · CD102 · CD103 · CD104 · CD105 · CD106 · CD107 (a, b) · CD108 · CD109 · CD110 · CD111 · CD112 · CD113 · CD114 · CD115 · CD116 · CD117 · CD118 · CD119 · CD120 (a, b) · CD121 (a, b) · CD122 · CD123 · CD124 · CD125 · CD126 · CD127 · CD129 · CD130 · CD131 · CD132 · CD133 · CD134 · CD135 · CD136 · CD137 · CD138 · CD140b · CD141 · CD142 · CD143 · CD144 · CD146 · CD147 · CD148 · CD150

151-200	CD151 · CD152 · CD153 · CD154 · CD155 · CD156 (a, b, c) · CD157 · CD158 (a, d, e, i, k) · CD159 (a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 (a, b) · CD168 · CD169 · CD170 · CD171 · CD172 (a, b, g) · CD174 · CD177 · CD178 · CD179 (a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200

201-250	CD201 · CD202b · CD204 · CD205 · CD206 · CD207 · CD208 · CD209 · CDw210 (a, b) · CD212 · CD213a (1, 2) · CD217 · CD218 (a, b) · CD220 · CD221 · CD222 · CD223 · CD224 · CD225 · CD226 · CD227 · CD228 · CD229 · CD230 · CD233 · CD234 · CD235 (a, b) · CD236 · CD238 · CD239 · CD240CE · CD240D · CD241 · CD243 · CD244 · CD246 · CD247- CD248 · CD249

251-300	CD252 · CD253 · CD254 · CD256 · CD257 · CD258 · CD261 · CD262 · CD264 · CD265 · CD266 · CD267 · CD268 · CD269 · CD271 · CD272 · CD273 · CD274 · CD275 · CD276 · CD278 · CD279 · CD280 · CD281 · CD282 · CD283 · CD284 · CD286 · CD288 · CD289 · CD290 · CD292 · CDw293 · CD294 · CD295 · CD297 · CD298 · CD299

301-350	CD300A · CD301 · CD302 · CD303 · CD304 · CD305 · CD306 · CD307 · CD309 · CD312 · CD314 · CD315 · CD316 · CD317 · CD318 · CD320 · CD321 · CD322 · CD324 · CD325 · CD326 · CD328 · CD329 · CD331 · CD332 · CD333 · CD334 · CD335 · CD336 · CD337 · CD338 · CD339 · CD340 · CD344 · CD349 · CD350

Cytokine receptors

Chemokine receptor
(GPCRs)

CC	CCR1/CCRL1 · CCR2 · CCRL2 · CCR3 · CCR4 · CCR5 · CCR6 · CCR7 · CCR8 · CCR9 · CCR10

CXC	IL-8 (CXCR1, CXCR2) · CXCR3 · CXCR4 · CXCR5 · CXCR6 · CXCR7

Other	CX3C (CX3CR1) · XC (XCR1) · CCBP2 · CMKLR1

TNF receptor

1-10	TNFRSF1 (CD120) · TNFRSF1A (CD120a) · TNFRSF1B (CD120b) · TNFRSF3 (Lymphotoxin beta receptor) · TNFRSF4 (CD134) · TNFRSF5 (CD40) · TNFRSF6 (FAS) · TNFRSF6B · TNFRSF7 (CD27) · TNFRSF8 (CD30) · TNFRSF9 (CD137)

11-20	TNFRSF10A (CD261) · TNFRSF10B (CD262) · TNFRSF10C (CD263) · TNFRSF10D (CD264) · TNFRSF11A (CD265/RANK) · TNFRSF11B (Osteoprotegerin) · TNFRSF12A (CD266) · TNFRSF13B (CD267) · TNFRSF13C · TNFRSF14 (CD268) · TNFRSF16 (Nerve growth factor receptor) · TNFRSF17 (CD269) · TNFRSF18 · TNFRSF19

21-25	TNFRSF21 · TNFRSF25 · TNFRSF27

JAK-STAT

Type I

γ-chain	Interleukin receptors (IL2R/IL2RA/IL2RB/IL15R, IL4R/IL13R/IL13RA1/IL13RA2, IL7R/IL7RA, IL9R, IL21R)

β-chain	Interleukin receptors (IL3R/IL3RA, IL5R/IL5RA) · GM-CSF

gp130	Interleukin receptors (IL6RA, 11/IL11RA, 27/IL27RA) · OSMR · LIFR · CNTFR

IL12RB1	Interleukin receptors (IL12R/IL12RB1/IL12RB2, IL23R23)

Other	other CSF receptors (EPO, G-CSF, Thrombopoietin) hormone receptor: GH · prolactin

Type II

Interleukin receptors (IL10R/IL10RA/IL10RB/IL22R/IL22RA2, IL20R/IL20RA/IL20RB, IL28R) · Interferon receptors (-α/β/IFNAR1/IFNAR2, -γ/IFNGR1/IFNGR2)

Ig superfamily

CSF1 · KIT · IL1 (IL1R1, IL1R2) · IL18R/IL18R1

IL-17 family

IL-17 (IL17RA, IL17RB, IL17RC, IL17RD, IL17RE)

S/T

TGF-beta (TGFBR1, TGFBR2)

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

TNFRSF13C

References

Further reading