BAALC

BAALC
Identifiers
Symbol BAALC
Entrez 79870
HUGO 14333
OMIM 606602
RefSeq NP_079088.1&rn=1 NP_001019543.1 NP_079088.1
UniProt Q8WXS3
Other data
Locus Chr. 8 q22.3

BAALC (Brain and Acute Leukemia, Cytoplasmic)is a gene that has been associated with acute myeloid leukemia.[1] The gene is conserved among mammals and is not found in lower organisms.[2][3] Tissues that express this gene develop from the neuroectoderm. [2] Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines [2].Among patients with acute myeloid leukemia, those overexpressing BAALC show distinctly poor prognosis, pointing to a key role of the BAALC products in leukemia.[3] Some sources suggest that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions[3].

References

  1. ^ Tanner SM, Austin JL, Leone G, et al. (November 2001). "BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13901–6. doi:10.1073/pnas.241525498. PMC 61139. PMID 11707601. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=61139. 
  2. ^ a b c http://www.genecards.org/cgi-bin/carddisp.pl?gene=BAALC
  3. ^ a b c http://www.pnas.org/content/98/24/13901.abstract

External links