B-cell prolymphocytic leukemia
B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.
It can involve deletions from chromosome 11 and chromosome 13.[1]
It has been suggested that some cases may represent a variant of mantle cell lymphoma.[2]
It has a relatively poor prognosis.[3]
Markers
A case has been described as CD20+, CD22+, and CD5-.[4]
It can also be CD5+.[5]
Another case was described as CD45+, CD19+, CD20+, CD5+, HLA-DR+, CD10-, CD23+/-, CD38+ and FMC7-.[6]
Treatment
Splenic irradiation has been used in the treatment.[7]
References
- ^ Lens D, Matutes E, Catovsky D, Coignet LJ (2000). "Frequent deletions at 11q 23 and 13q14 in B cell prolymphocytic leukemia (B-PLL)". Leukemia 14 (3): 427–30. doi:10.1038/sj.leu.2401644. PMID 10720137.
- ^ Ruchlemer R, Parry-Jones N, Brito-Babapulle V, et al. (May 2004). "B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia". Br. J. Haematol. 125 (3): 330–6. doi:10.1111/j.1365-2141.2004.04913.x. PMID 15086413.
- ^ Del Giudice I, Davis Z, Matutes E, et al. (2006). "IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL)". Leukemia 20 (7): 1231–7. doi:10.1038/sj.leu.2404238. PMID 16642047.
- ^ Yamamoto K, Hamaguchi H, Nagata K, Shibuya H, Takeuchi H (April 1998). "Splenic irradiation for prolymphocytic leukemia: is it preferable as an initial treatment or not?". Jpn. J. Clin. Oncol. 28 (4): 267–9. doi:10.1093/jjco/28.4.267. PMID 9657013. http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=9657013.
- ^ "Pathology". http://www.med-ed.virginia.edu/courses/path/innes/wcd/lympleuk.cfm. Retrieved 2009-01-31.
- ^ Crisostomo RH, Fernandez JA, Caceres W (May 2007). "Complex karyotype including chromosomal translocation (8;14) (q24;q32) in one case with B-cell prolymphocytic leukemia". Leuk. Res. 31 (5): 699–701. doi:10.1016/j.leukres.2006.06.010. PMID 16997373. http://linkinghub.elsevier.com/retrieve/pii/S0145-2126(06)00218-9.
- ^ Nakashima H, Saito B, Ariizumi H, Matsuda I, Nakamaki T, Tomoyasu S (December 2008). "Splenic irradiation as a successful treatment for an elderly patient with B-cell prolymphocytic leukemia" (– Scholar search). Rinsho Ketsueki 49 (12): 1619–22. PMID 19110524. http://joi.jlc.jst.go.jp/JST.JSTAGE/rinketsu/49.1619?from=PubMed.
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By development/
marker
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see immunoproliferative immunoglobulin disorders
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By infection
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By development/
marker
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By infection
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T or NK
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Lymphoid+myeloid
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| Cutaneous lymphoid hyperplasia |
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cell/phys/auag/auab/comp, igrc
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