Azepindole

Azepindole

Systematic (IUPAC) name
2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	26304-61-0^N
ATC code	?
PubChem	CID 33471
ChemSpider	30893^Y
UNII	6BB6FW9T8J^Y
KEGG	D03035^Y
ChEMBL	CHEMBL10758^Y
Chemical data
Formula	C₁₂H₁₄N₂
Mol. mass	186.25 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C12H14N2/c1-2-5-12-10(4-1)8-11-9-13-6-3-7-14(11)12/h1-2,4-5,8,13H,3,6-7,9H2^Y Key:FEJCIXJKPISCJV-UHFFFAOYSA-N^Y
N(what is this?) (verify)

Azepindole (McN-2453) is a tricyclic compound with antidepressant and antihypertensive effects that was developed in the late 1960s but was never marketed.^[1]

References

^ Dictionary of pharmacological agents - Google Books. http://books.google.com/books?id=A0THacd46ZsC&lpg=RA2-PA1921&dq=azepindole&as_brr=3&pg=RA2-PA1921#v=onepage&q=azepindole&f=false.

Antidepressants (N06A)

Specific reuptake inhibitors (RIs), enhancers (REs), and releasing agents (RAs)

Selective serotonin reuptake inhibitors (SSRIs)	Alaproclate • Citalopram • Escitalopram • Femoxetine • Fluoxetine^# • Fluvoxamine • Indalpine • Ifoxetine • Litoxetine • Lubazodone • Panuramine • Paroxetine • Pirandamine • Seproxetine • Sertraline^# • Zimelidine^‡

Serotonin–norepinephrine reuptake inhibitors (SNRIs)	Bicifadine • Clovoxamine • Desvenlafaxine • Duloxetine • Levomilnacipran • Eclanamine • Milnacipran • Sibutramine • Venlafaxine

Serotonin–norepinephrine–dopamine reuptake inhibitors (SNDRIs)	Brasofensine • BTS-74,398 • Cocaine • Diclofensine • DOV-21,947 • DOV-102,677 • DOV-216,303 • EXP-561 • Fezolamine • JNJ-7925476 • NS-2359 • PRC200-SS • Pridefine • SEP-225,289 • SEP-227,162 • Tesofensine

Norepinephrine reuptake inhibitors (NRIs)	Amedalin • Atomoxetine/Tomoxetine • Binedaline • Ciclazindol • Daledalin • Esreboxetine • Lortalamine • Mazindol • Nisoxetine • Reboxetine • Talopram • Talsupram • Tandamine • Viloxazine

Dopamine reuptake inhibitors (DRIs)	Medifoxamine • Vanoxerine

Norepinephrine-dopamine reuptake inhibitors (NDRIs)	Amineptine • Bupropion/Amfebutamone^# • Cilobamine • Manifaxine • Methylphenidate • Nomifensine • Radafaxine • Tametraline

Norepinephrine-dopamine releasing agents (NDRAs)	Amphetamine • Befuraline • Lisdexamfetamine • Methamphetamine • Phenethylamine • Piberaline • Tranylcypromine

Serotonin-norepinephrine-dopamine releasing agents (SNDRAs)	4-Methyl-αMT • αET/Etryptamine • αMT/Metryptamine

Selective serotonin reuptake enhancers (SSREs)	Tianeptine

Others	Indeloxazine • Teniloxazine • Tramadol • Viqualine

Receptor antagonists and/or reuptake inhibitors

Serotonin antagonists and reuptake inhibitors (SARIs)	Etoperidone • Nefazodone • Trazodone

Noradrenergic and specific serotonergic antidepressants (NaSSAs)	Aptazapine • Esmirtazapine • Mianserin • Mirtazapine • Setiptiline/Teciptiline

Norepinephrine-dopamine disinhibitors (NDDIs)	Agomelatine

Serotonin modulators and stimulators (SMSs)	Vortioxetine

Others	Tedatioxetine • Vilazodone

Heterocyclic antidepressants (bi-, tri-, and tetracyclics)

Bicyclics	Tiazesim

Tricyclics	Amezepine • Amineptine • Amitriptyline^# • Amitriptylinoxide • Azepindole • Butriptyline • Cianopramine • Clomipramine • Cotriptyline • Cyanodothiepin • Demexiptiline • Depramine/Balipramine • Desipramine • Dibenzepin • Dimetacrine • Dosulepin/Dothiepin • Doxepin • Enprazepine • Fluotracen • Hepzidine • Homopipramol • Imipramine • Imipraminoxide • Intriptyline • Iprindole • Ketipramine • Litracen • Lofepramine • Losindole • Mariptiline • Melitracen • Metapramine • Mezepine • Naranol • Nitroxazepine • Nortriptyline • Noxiptiline • Octriptyline • Opipramol • Pipofezine • Propizepine • Protriptyline • Quinupramine • Tampramine • Tianeptine • Tienopramine • Trimipramine;

Tetracyclics	Amoxapine • Aptazapine • Azipramine • Ciclazindol • Ciclopramine • Esmirtazapine • Maprotiline • Mazindol • Mianserin • Mirtazapine • Oxaprotiline • Setiptiline/Teciptiline

Monoamine oxidase inhibitors (MAOIs)

Nonselective	Irreversible: Benmoxin • Echinopsidine • Iproclozide • Iproniazid • Isocarboxazid • Mebanazine • Metfendrazine • Nialamide • Octamoxin • Phenelzine • Pheniprazine • Phenoxypropazine • Pivalylbenzhydrazine • Safrazine • Tranylcypromine; Reversible: Caroxazone • Paraxazone;• Quercetin;

MAO_A-Selective	Irreversible: Clorgiline; Reversible: Amiflamine • Bazinaprine • Befloxatone • Befol • Berberine • Brofaromine • Cimoxatone • Esuprone • Harmala Alkaloids (Harmine, Harmaline, Tetrahydroharmine, Harman, Norharman, etc) • Methylene Blue • Metralindole • Minaprine • Moclobemide • Pirlindole • Sercloremine • Tetrindole • Toloxatone • Tyrima;

MAO_B-Selective	Irreversible: Ladostigil • Mofegiline • Pargyline • Rasagiline • Selegiline; Reversible: Lazabemide • Milacemide

Azapirones and other 5-HT_1A receptor agonists

Alnespirone • Aripiprazole • Befiradol • Buspirone • Eptapirone • Flesinoxan • Flibanserin • Gepirone • Ipsapirone • Oxaflozane • Tandospirone • Vilazodone • Zalospirone

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: PSO/PSI

mepr

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc(eval/thrp), drug(N5A/5B/5C/6A/6B/6D)

Sympatholytic (and closely related) antihypertensives (C02)

Sympatholytics
(antagonize α-adrenergic
vasoconstriction)

Central

α₂ agonist	Clonidine • Guanfacine • Methyldopa #

Adrenergic release inhibitors	Bethanidine • Bretylium • Debrisoquine • Guanadrel • Guanazodine • Guanethidine • Guanoclor • Guanoxan • Guanazodine • Guanoxabenz • Guanoxan

Imidazoline receptor agonist	Moxonidine • Rilmenidine

Ganglion-blocking/nicotinic antagonist	Mecamylamine • Pentolinium • Trimethaphan

Peripheral

Indirect

MAOI	Pargyline

Adrenergic uptake inhibitor	Rescinnamine • Reserpine

Tyrosine hydroxylase inhibitor	Metirosine

Direct

α₁ blockers	Prazosin • Indoramin • Trimazosin • Doxazosin • Urapidil

Non-selective α blocker	Phentolamine

Other antagonists

Serotonin antagonist	Ketanserin

Endothelin antagonist (for PH)	dual (Bosentan) • selective (Ambrisentan, Sitaxentan)

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)

Tricyclics

Classes	Acridine • Anthracene • Dibenzazepine • Dibenzocycloheptene • Dibenzodiazepine • Dibenzothiazepine • Dibenzothiepin • Dibenzoxazepine • Dibenzoxepin • Phenothiazine • Pyridazinobenzoxazine • Pyridinobenzodiazepine • Thioxanthene

Antidepressants	7-OH-Amoxapine • Amezepine • Amineptine • Amitriptyline • Amitriptylinoxide • Amoxapine • Aptazapine • Azepindole • Azipramine • Butriptyline • Cianopramine • Ciclazindol • Ciclopramine • Clomipramine • Cotriptyline • Cyanodothiepin • Demexiptiline • Depramine/Balipramine • Desipramine • Dibenzepin • Dimetacrine • Dosulepin/Dothiepin • Doxepin • Enprazepine • Esmirtazapine • Fluotracen • Hepzidine • Homopipramol • Imipramine • Imipraminoxide • Intriptyline • Iprindole • Ketipramine • Litracen • Lofepramine • Losindole • Loxapine • Maprotiline • Mariptiline • Mazindol • Melitracen • Metapramine • Mezepine • Mianserin • Mirtazapine • Naranol • Nitroxazepine • Nortriptyline • Noxiptiline • Octriptyline • Opipramol • Oxaprotiline • Pipofezine • Pirandamine • Propizepine • Protriptyline • Quinupramine • Setiptiline/Teciptiline • Tandamine • Tampramine • Tianeptine • Tienopramine • Trimipramine

Antihistamines	Alimemazine • Azatadine • Clobenzepam • Cyproheptadine • Dacemazine • Deptropine • Desloratadine • Epinastine • Etymemazine • Hydroxyethylpromethazine • Isopromethazine • Isothipendyl • Ketotifen • Latrepirdine • Loratadine • Mebhydrolin • Mequitazine • Methdilazine • Olopatadine • Oxomemazine • Phenindamine • Pimethixene • Promethazine • Propiomazine • Rupatadine • Thiazinamium

Antipsychotics	Acetophenazine • Amoxapine • Asenapine • Butaclamol • Butaperazine • Carphenazine • Carpipramine • Chlorpromazine • Chlorprothixene • Ciclindole • Clocapramine • Clomacran • Clorotepin • Clotiapine • Clozapine • Cyanothepin • Doclothepin • Docloxythepin • Erizepine • Flucindole • Flumezapine • Fluotracen • Flupentixol • Fluphenazine • Gevotroline • Homopipramol • Isofloxythepin • Levomepromazine/Methotrimeprazine • Loxapine • Maroxepin • Meperathiepin • Mesoridazine • Metitepine • Metoxepin • Mosapramine • Naranol • Octomethothepin • Olanzapine • Oxyclothepin • Oxyprothepin • Peradithiepin • Perathiepin • Perazine • Perphenazine • Periciazine • Piperacetazine • Pipotiazine • Piquindone • Prochlorperazine • Promazine • Prothipendyl • Quetiapine • Sulforidazine • Thiethylperazine • Thiopropazate • Thioridazine • Thiothixene • Tilozepine • Trifluoperazine • Triflupromazine • Trifluthepin • Zotepine • Zuclopenthixol

Others	Atiprosin • Carbamazepine • Carvedilol • Cyclobenzaprine • Darenzepine • Elanzepine • Eslicarbazepine acetate • Etazepine • Licarbazepine • Methylene Blue • Monatepil • Nuvenzepine • Oxcarbazepine • Oxitriptyline • Pirenzepine • Pirolate • Pitrazepin • Pizotifen • Profenamine • Rispenzepine • Serazapine • Siltenzepine • Telenzepine • Zolenzepine

Azepindole

See also

References