Autoschizis

Autoschizis is a term derived from the Greek roots "auto" meaning self, and "skhizein" to split. It used to describe a novel form of cancer cell death characterized by a reduction in cell size that occurs due to the loss of cytoplasm through self-excision (the cell splits open) without the loss of cell organelles, morphologic degradation of the cells nucleus and nucleolus without the formation of apoptotic bodies and destruction of the cell membrane. The cell death results from karyorrhexis and karyolysis.[1] Autoschizis can be initiated via in vivo treatment with Vitamin C (VC), synthetic Vitamin K (VK3) or a combination of both. The treatment has been tested on various types of cancers with positive results.[2]

References

  1. ^ "Autoschizis: a novel cell death". Biochem. Pharmacol. 63 (10): 1773–83. May 2002. doi:10.1016/S0006-2952(02)00904-8. PMID 12034362. 
  2. ^ Gilloteaux J, et al.Autoschizis of human ovarian carcinoma cells: scanning electron and light microscopy of a new cell death induced by sodium ascorbate: menadione treatment. Scanning. 2003 May-Jun;25(3):137-49. PMID 12866647