Atamestane

Atamestane

Systematic (IUPAC) name
(8R,9S,10S,13S,14S)-1,10,13-Trimethyl-7,8,9,11,12, 14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
Clinical data
Pregnancy cat.	?
Legal status	? (UK)
Identifiers
CAS number	96301-34-7^N
ATC code	None
PubChem	CID 57050
ChemSpider	51438^Y
UNII	62GA3K28B6^Y
Chemical data
Formula	C₂₀H₂₆O₂
Mol. mass	298.419 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C20H26O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h10-11,15-17H,4-9H2,1-3H3/t15-,16-,17-,19-,20-/m0/s1^Y Key:PEPMWUSGRKINHX-TXTPUJOMSA-N^Y
N(what is this?) (verify)

Atamestane is an aromatase inhibitor that is being studied in the treatment of cancer. Atamestane blocks the production of the hormone estrogen in the body.

It is selective.^[1]

References

^ el Etreby MF (March 1993). "Atamestane: an aromatase inhibitor for the treatment of benign prostatic hyperplasia. A short review". J. Steroid Biochem. Mol. Biol. 44 (4-6): 565–72. doi:10.1016/0960-0760(93)90260-4. PMID 7682838.

ElEtreby MF (1993) Atamestane: an aromatase inhibitor for the treatment of benign prostatic hyperplasia. A short review. J Steroid Biochem Mol Biol. 44(4-6):565-72. PMID 7682838

External links

Atamestane entry in the public domain NCI Dictionary of Cancer Terms

This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

Estrogens and progestogens (G03C-D, L02)

Progestogens/
progestins
(progesterone)

Agonist

1st	Norpregnene (Norethisterone^#/Norethisterone acetate • Ethynodiol diacetate)

2nd	Norpregnene (Levonorgestrel^#/Norgestrel/Norelgestromin)

3rd	19-nortestosterone (Desogestrel/Etonogestrel • Gestodene • Norgestimate)

4th	Androstene (Drospirenone) • 19-norprogesterone (Nomegestrol • Promegestone • Trimegestone) • 19-nortestosterone (Dienogest)

17-OH	Chlormadinone • Cyproterone • Medroxyprogesterone/Medroxyprogesterone 17-acetate^# • Megestrol

Other/ ungrouped	Pregnenedione (Gestonorone) • Pregnene (Ethisterone) • Pregnadiene (Medrogestone • Melengestrol) • Norpregnane (Norgestrienone) • Lynestrenol • Norethynodrel • Tibolone • Dydrogesterone • Quingestanol

Antiprogestin/
SPRM

antagonist: Mifepristone

Asoprisnil • CDB-4124 • Ulipristal acetate

Estrogens

Agonist

Steroidal	Diosgenin • Estradiol (Ethinylestradiol^#/Mestranol • Estradiol 17 beta-cypionate^# • Polyestradiol phosphate) • Estrone (Estrone sulfate) • Estriol • Promestriene • Equilenin • Equilin

Nonsteroidal	Chlorotrianisene • Dienestrol • Fosfestrol • Diethylstilbestrol • Zeranol

Antiestrogen/
SERM

Afimoxifene • Arzoxifene • Bazedoxifene • Cyclofenil • Lasofoxifene • Ormeloxifene • Raloxifene • Tamoxifen • Toremifene

Clomifene^# • Mepitiostane • Nafoxidine

pure antagonist: Fulvestrant

Aromatase inhibitors

nonselective: Aminoglutethimide • Testolactone

selective: Anastrozole • Atamestane • Exemestane • Fadrozole • Formestane • Letrozole • Vorozole

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: ♀ FRS

anat/phys/devp

noco/cong/npls, sysi/epon

proc/asst, drug (G1/G2B/G3CD)