Arachidonyl-2'-chloroethylamide

Arachidonyl-2'-chloroethylamide
IUPAC name

N-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Other names

Arachidonyl-2'-chloroethylamide; ACEA
Identifiers
CAS number 220556-69-4 Y
PubChem 5311006
ChemSpider 4470547 Y
Jmol-3D images Image 1
Properties
Molecular formula C22H36ClNO
Molar mass 365.98 g mol−1
Solubility in other solvents soluble in ethanol, chloroform, THF and DMSO
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of the cannabinoid receptor 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R) (Ki = 1.4 nM for CB1R; Ki = 3100 nM for CB2R). [1]

References

  1. ^ Hillard, CJ; Manna, S; Greenberg, MJ; Dicamelli, R; Ross, RA; Stevenson, LA; Murphy, V; Pertwee, RG et al. (1999). "Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)". The Journal of pharmacology and experimental therapeutics 289 (3): 1427–33. PMID 10336536.