Low density lipoprotein receptor-related protein 8
Low-density lipoprotein receptor-related protein 8 is a protein that in humans is encoded by the LRP8 gene.[1][2][3]
Low density lipoprotein receptor-related protein 8, or LRP8 (also Apolipoprotein E Receptor 2; ApoER2) is a member of the LDL receptor family that plays a role in endocytosis and signal transduction. Together with VLDLR it is able to bind reelin, leading to the phosphorylation of DAB1, which binds on its cytosolic tail.
This gene encodes an apolipoprotein E receptor, a member of the low density lipoprotein receptor (LDLR) family. Apolipoprotein E is a small lipophilic plasma protein and a component of lipoproteins such as chylomicron remnants, very low density lipoprotein (VLDL), and high density lipoprotein (HDL). The apolipoprotein E receptor is involved in cellular recognition and internalization of these lipoproteins. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.[3]
ApoER2 also regulates selenium intake into cells through endocytosis of SEPP1.[4]
Interactions
Low density lipoprotein receptor-related protein 8 has been shown to interact with SNX17[5] and Reelin.[6][7]
References
- ^ Kim DH, Iijima H, Goto K, Sakai J, Ishii H, Kim HJ, Suzuki H, Kondo H, Saeki S, Yamamoto T (Jun 1996). "Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain". J Biol Chem 271 (14): 8373–80. doi:10.1074/jbc.271.14.8373. PMID 8626535.
- ^ Kim DH, Magoori K, Inoue TR, Mao CC, Kim HJ, Suzuki H, Fujita T, Endo Y, Saeki S, Yamamoto TT (May 1997). "Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene". J Biol Chem 272 (13): 8498–504. doi:10.1074/jbc.272.13.8498. PMID 9079678.
- ^ a b "Entrez Gene: LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7804.
- ^ Olson GE, Winfrey VP, Nagdas SK, Hill KE, Burk RF (April 2007). "Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testis". J. Biol. Chem. 282 (16): 12290–7. doi:10.1074/jbc.M611403200. PMID 17314095. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=17314095.
- ^ Stockinger, Walter; Sailler Beate, Strasser Vera, Recheis Burgi, Fasching Daniela, Kahr Larissa, Schneider Wolfgang J, Nimpf Johannes (Aug. 2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor". EMBO J. (England) 21 (16): 4259–67. doi:10.1093/emboj/cdf435. ISSN 0261-4189. PMC 126172. PMID 12169628. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126172.
- ^ Andersen, Olav M; Benhayon David, Curran Tom, Willnow Thomas E (Aug. 2003). "Differential binding of ligands to the apolipoprotein E receptor 2". Biochemistry (United States) 42 (31): 9355–64. doi:10.1021/bi034475p. ISSN 0006-2960. PMID 12899622.
- ^ Benhayon, David; Magdaleno Susan, Curran Tom (Apr. 2003). "Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1". Brain Res. Mol. Brain Res. (Netherlands) 112 (1–2): 33–45. doi:10.1016/S0169-328X(03)00032-9. ISSN 0169-328X. PMID 12670700.
Further reading
- Clatworthy AE, Stockinger W, Christie RH, et al. (1999). "Expression and alternate splicing of apolipoprotein E receptor 2 in brain". Neuroscience 90 (3): 903–11. doi:10.1016/S0306-4522(98)00489-8. PMID 10218790.
- Sun XM, Soutar AK (1999). "Expression in vitro of alternatively spliced variants of the messenger RNA for human apolipoprotein E receptor-2 identified in human tissues by ribonuclease protection assays". Eur. J. Biochem. 262 (1): 230–9. doi:10.1046/j.1432-1327.1999.00394.x. PMID 10231386.
- Trommsdorff M, Gotthardt M, Hiesberger T, et al. (1999). "Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2". Cell 97 (6): 689–701. doi:10.1016/S0092-8674(00)80782-5. PMID 10380922.
- Riddell DR, Vinogradov DV, Stannard AK, et al. (1999). "Identification and characterization of LRP8 (apoER2) in human blood platelets". J. Lipid Res. 40 (10): 1925–30. PMID 10508213.
- D'Arcangelo G, Homayouni R, Keshvara L, et al. (1999). "Reelin is a ligand for lipoprotein receptors". Neuron 24 (2): 471–9. doi:10.1016/S0896-6273(00)80860-0. PMID 10571240.
- Korschineck I, Ziegler S, Breuss J, et al. (2001). "Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue". J. Biol. Chem. 276 (16): 13192–7. doi:10.1074/jbc.M011795200. PMID 11152697.
- Riddell DR, Sun XM, Stannard AK, et al. (2001). "Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane". J. Lipid Res. 42 (6): 998–1002. PMID 11369809.
- Weeber EJ, Beffert U, Jones C, et al. (2002). "Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning". J. Biol. Chem. 277 (42): 39944–52. doi:10.1074/jbc.M205147200. PMID 12167620.
- Stockinger W, Sailler B, Strasser V, et al. (2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor". EMBO J. 21 (16): 4259–67. doi:10.1093/emboj/cdf435. PMC 126172. PMID 12169628. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126172.
- Ma SL, Ng HK, Baum L, et al. (2003). "Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease". Neurosci. Lett. 332 (3): 216–8. doi:10.1016/S0304-3940(02)00942-4. PMID 12399018.
- Koch S, Strasser V, Hauser C, et al. (2003). "A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling". EMBO J. 21 (22): 5996–6004. doi:10.1093/emboj/cdf599. PMC 137191. PMID 12426372. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137191.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Sun XM, Soutar AK (2003). "The transmembrane domain and PXXP motifs of ApoE receptor 2 exclude it from carrying out clathrin-mediated endocytosis". J. Biol. Chem. 278 (22): 19926–32. doi:10.1074/jbc.M302047200. PMID 12621059.
- Benhayon D, Magdaleno S, Curran T (2003). "Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1". Brain Res. Mol. Brain Res. 112 (1–2): 33–45. doi:10.1016/S0169-328X(03)00032-9. PMID 12670700.
- Sacre SM, Stannard AK, Owen JS (2003). "Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells". FEBS Lett. 540 (1–3): 181–7. doi:10.1016/S0014-5793(03)00261-8. PMID 12681505.
- Lutters BC, Derksen RH, Tekelenburg WL, et al. (2003). "Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'". J. Biol. Chem. 278 (36): 33831–8. doi:10.1074/jbc.M212655200. PMID 12807892.
- Bajari TM, Strasser V, Nimpf J, Schneider WJ (2003). "A model for modulation of leptin activity by association with clusterin". FASEB J. 17 (11): 1505–7. doi:10.1096/fj.02-1106fje. PMID 12824284.
- May P, Bock HH, Nimpf J, Herz J (2003). "Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase". J. Biol. Chem. 278 (39): 37386–92. doi:10.1074/jbc.M305858200. PMID 12871934.
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